DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elgi and Lnx1

DIOPT Version :9

Sequence 1:	NP_001261904.1	Gene:	elgi / 39735	FlyBaseID:	FBgn0283649	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001101828.1	Gene:	Lnx1 / 360926	RGDID:	1308159	Length:	728	Species:	Rattus norvegicus

Alignment Length:	346	Identity:	69/346 - (19%)
Similarity:	107/346 - (30%)	Gaps:	128/346 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EVDEELTCPICSGVLEDPLQAVMCEHAFCRGCINEWLTRQPTCPVDRNSLTTANLRAVPRILRNL 75
            :||::|.|.||...|.|||. ..|.|.:|..|:..:|..:..|||||..:...:.:....::..|
  Rat    38 DVDDDLVCHICLQALLDPLD-TPCGHTYCTLCLTNFLVEKDFCPVDRKPVVLQHCKKSNILVNKL 101

  Fly    76 LSRLSITC----------------------------------------DNAPYGCTAV------- 93
            |::|.:.|                                        |..|.||.::
  Rat   102 LNKLLVNCPFTEHCSEVLQRCNLQYHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLTATTLSP 166

  Fly    94 ----------------LKLDAYNSHLD--ECIHNPK----------RPFPCEKGCGFDIPKDELK 130
                            |...||.|.::  |.:.||.          |||          .:..::
  Rat   167 EVSAAATISLMTDEPGLDNPAYTSSVEDGEPVTNPSDTGRSNRTRARPF----------ERSTMR 221

  Fly   131 DHNCVRELRTLIVKQTEKMGELKSELTDQ------QLTINEL-KRELQLFKD----FMRAMRV-- 182
            ..:..:..|.|...:..|.|...:...||      ..|:.|: .|...|..|    .::..||
  Rat   222 SRSFKKINRALSALRRTKSGSAVANHADQGRDNSENDTVPEVFPRLFHLIPDGEITSIKINRVDP 286

  Fly   183 ------------SNPAMRAIADQMERDEVI-RWSSTLPRARVTRWGGM-------------ISTP 221
                        ..|.:..|...:.||.|| |....||...:.:..||             :..|
  Rat   287 NESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQP 351

  Fly   222 DDALQLMIKRA---LSESGCP 239
            ...|:|.:.|.   .|.|..|
  Rat   352 CQVLRLTVLREQKFRSRSNAP 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elgi	NP_001261904.1	RING	17..55	CDD:238093	13/37 (35%)
		Sina	83..>157	CDD:302762	19/148 (13%)
		USP8_interact	137..315	CDD:286082	31/145 (21%)
Lnx1	NP_001101828.1	RING	45..81	CDD:214546	13/36 (36%)
		DegQ	<260..364	CDD:223343	21/103 (20%)
		PDZ_signaling	276..360	CDD:238492	16/83 (19%)
		PDZ_signaling	384..464	CDD:238492
		PDZ_signaling	506..589	CDD:238492
		PDZ_signaling	637..721	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810