DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elgi and Traf6

DIOPT Version :9

Sequence 1:	NP_001261904.1	Gene:	elgi / 39735	FlyBaseID:	FBgn0283649	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001290202.1	Gene:	Traf6 / 22034	MGIID:	108072	Length:	530	Species:	Mus musculus

Alignment Length:	334	Identity:	63/334 - (18%)
Similarity:	104/334 - (31%)	Gaps:	140/334 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GYDVNRFQGEVDEELTCPICSGVLEDPLQAVMCEHAFCRGCINEWL-TRQPTCPVDRNSLTTANL 65
            |||| .|...::.:..||||...|.:.:| ..|.|.||:.||.:.: .....||||...|....|
Mouse    55 GYDV-EFDPPLESKYECPICLMALREAVQ-TPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQL 117

  Fly    66 RAVPRILRNLLSRLSITCDNAPYGCTAVLKLDAYNSH---------------------------L 103
            .......|.:|| |::.|.|.  ||...::|.....|                           :
Mouse   118 FPDNFAKREILS-LTVKCPNK--GCLQKMELRHLEDHQVHCEFALVNCPQCQRPFQKCQVNTHII 179

  Fly   104 DEC--------------------IHN------------------------------PKRPFPCE- 117
            ::|                    ||:                              |..|.||.
Mouse   180 EDCPRRQVSCVNCAVSMAYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPIPCTF 244

  Fly   118 --KGCGFDIPKDELKDH---------------------------------NC----------VRE 137
              .||...:.::.|..|                                 .|          :::
Mouse   245 SVFGCHEKMQRNHLARHLQENTQLHMRLLAQAVHNVNLALRPCDAASPSRGCRPEDPNYEETIKQ 309

  Fly   138 LRTLIVKQTEKMGELKSELTDQQLTINELKRELQLFKDFMRAM-----------RVSNPAMRAIA 191
            |.:.:|:|..::.||.:::..|.:.:.||||.::..:|.:..|           ::.|..|...:
Mouse   310 LESRLVRQDHQIRELTAKMETQSMYVGELKRTIRTLEDKVAEMEAQQCNGIYIWKIGNFGMHLKS 374

  Fly   192 DQMERDEVI 200
            .:.||..||
Mouse   375 QEEERPVVI 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elgi	NP_001261904.1	RING	17..55	CDD:238093	13/38 (34%)
		Sina	83..>157	CDD:302762	23/196 (12%)
		USP8_interact	137..315	CDD:286082	18/75 (24%)
Traf6	NP_001290202.1	Interaction with TAX1BP1. /evidence=ECO:0000250	1..362		57/311 (18%)
		RING	69..107	CDD:238093	13/38 (34%)
		zf-TRAF	204..261	CDD:280357	8/56 (14%)
		SlyX	304..>356	CDD:294687	12/51 (24%)
		MATH_TRAF6	359..508	CDD:239745	6/25 (24%)
		Interaction with TANK. /evidence=ECO:0000250\|UniProtKB:Q9Y4K3	363..530		6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D918518at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820