DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elgi and Traf5

DIOPT Version :9

Sequence 1:	NP_001261904.1	Gene:	elgi / 39735	FlyBaseID:	FBgn0283649	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_035763.2	Gene:	Traf5 / 22033	MGIID:	107548	Length:	558	Species:	Mus musculus

Alignment Length:	293	Identity:	73/293 - (24%)
Similarity:	108/293 - (36%)	Gaps:	82/293 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RFQGEVDEELTCPICSGVLEDPLQAVMCEHAFCRGCINEW--LTRQPTCPVDRNSLTTANLRAVP 69
            :|..:::|...|..|..||.:|.| ..|.|.||:.||...  |...|.||||:..:....:....
Mouse    34 QFVEQLEERYKCAFCHSVLHNPHQ-TGCGHRFCQQCIRSLRELNSVPICPVDKEVIKPQEVFKDN 97

  Fly    70 RILRNLLSRLSITCDNAPYGCTAVLKLDAYNSHLDECIHNPKRPFPC-EKGCGFDIPKDELKDH- 132
            ...|.:|: |.:.|.||| ||.|.:.|..:..||..|..   :..|| .:.|...:.:.::|:|
Mouse    98 CCKREVLN-LHVYCKNAP-GCNARIILGRFQDHLQHCSF---QAVPCPNESCREAMLRKDVKEHL 157

  Fly   133 ---------NCVRELRTLIVKQTEKMGELKSELTDQQLTINELKRELQLFKDFMRAMRVSNPAMR 188
                     .|:...|.::|          :.|.|.:             ::...|..||.|.
Mouse   158 SAYCRFREEKCLYCKRDIVV----------TNLQDHE-------------ENSCPAYPVSCPN-- 197

  Fly   189 AIADQMERDEVIRWSSTLPRARVTRWGGMISTPDDALQLMIKRALSESGCP-PHI-------LDS 245
                        |...|:|||||..  .:...|:           :|..|| .|.       ..:
Mouse   198 ------------RCVQTIPRARVNE--HLTVCPE-----------AEQDCPFKHYGCTVKGKRGN 237

  Fly   246 LMEFCHERR--WPRGLSSLETR-QTNRRIYDNY 275
            |:|  |||.  ....|..||.. |..:||.|.|
Mouse   238 LLE--HERAALQDHMLLVLEKNYQLEQRISDLY 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elgi	NP_001261904.1	RING	17..55	CDD:238093	15/39 (38%)
		Sina	83..>157	CDD:302762	19/84 (23%)
		USP8_interact	137..315	CDD:286082	33/150 (22%)
Traf5	NP_035763.2	mRING-HC-C3HC3D_TRAF5	43..85	CDD:319556	17/42 (40%)
		zf-TRAF	128..183	CDD:280357	12/67 (18%)
		zf-TRAF	185..241	CDD:424248	18/84 (21%)
		Smc	<237..>419	CDD:224117	13/34 (38%)
		Interaction with EIF2AK2/PKR. /evidence=ECO:0000250	345..558
		MATH_TRAF5	404..551	CDD:239749
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910