DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elgi and TRAIP

DIOPT Version :9

Sequence 1:	NP_001261904.1	Gene:	elgi / 39735	FlyBaseID:	FBgn0283649	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_005870.2	Gene:	TRAIP / 10293	HGNCID:	30764	Length:	469	Species:	Homo sapiens

Alignment Length:	202	Identity:	44/202 - (21%)
Similarity:	74/202 - (36%)	Gaps:	41/202 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CPICSGVLED--PLQAVMCEHAFCRGCINEWLTRQP--TCPVDRNSLTTANLRAVPRILRNLLSR 78
            |.|||...:.  .:.|:.|.|.|...|:.:|....|  |||..|..:....      |:..|...
Human     7 CTICSDFFDHSRDVAAIHCGHTFHLQCLIQWFETAPSRTCPQCRIQVGKRT------IINKLFFD 65

  Fly    79 LSITCDNAPYGCTAVLKLDAYNSHLDEC------IHNPKRPFPCEKGCGFDIPKDELKDHNCVRE 137
            |:...:|       ||..:...:.||..      ....||    :.....|..:|.|::.|..
Human    66 LAQEEEN-------VLDAEFLKNELDNVRAQLSQKDKEKR----DSQVIIDTLRDTLEERNAT-- 117

  Fly   138 LRTLIVKQTEKMGE---LKSELTDQQLTINELKRELQLFKDFMRAMRVSNPAMRAI-----ADQM 194
                :|...:.:|:   |.|.|..|...:.:.:.|.:..::..|.:|.....|..|     :.:.
Human   118 ----VVSLQQALGKAEMLCSTLKKQMKYLEQQQDETKQAQEEARRLRSKMKTMEQIELLLQSQRP 178

  Fly   195 ERDEVIR 201
            |.:|:||
Human   179 EVEEMIR 185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elgi	NP_001261904.1	RING	17..55	CDD:238093	13/40 (33%)
		Sina	83..>157	CDD:302762	15/82 (18%)
		USP8_interact	137..315	CDD:286082	15/73 (21%)
TRAIP	NP_005870.2	RING-H2_TRAIP	6..50	CDD:319394	14/42 (33%)
		RING-H2 finger (C3H2C3-type)	7..49	CDD:319394	14/41 (34%)
		SMC_N	<68..>279	CDD:330553	26/135 (19%)
		Interaction with CYLD. /evidence=ECO:0000269\|PubMed:14676304	211..469
		PIP-box. /evidence=ECO:0000269\|PubMed:26711499	460..469
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910