DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elgi and RNF41

DIOPT Version :9

Sequence 1:	NP_001261904.1	Gene:	elgi / 39735	FlyBaseID:	FBgn0283649	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001229755.1	Gene:	RNF41 / 10193	HGNCID:	18401	Length:	317	Species:	Homo sapiens

Alignment Length:	315	Identity:	181/315 - (57%)
Similarity:	248/315 - (78%)	Gaps:	0/315 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDVNRFQGEVDEELTCPICSGVLEDPLQAVMCEHAFCRGCINEWLTRQPTCPVDRNSLTTANL 65
            |||||.||||:|||:|.|||||||||:|:||..||||||..||.:|.::|.||||||:.:|.|:|
Human     1 MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHL 65

  Fly    66 RAVPRILRNLLSRLSITCDNAPYGCTAVLKLDAYNSHLDECIHNPKRPFPCEKGCGFDIPKDELK 130
            |.||||:||:||:|.|.||||.:||:||::||...|||.:|.||||||..||:|||.::|||||.
Human    66 RPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELP 130

  Fly   131 DHNCVRELRTLIVKQTEKMGELKSELTDQQLTINELKRELQLFKDFMRAMRVSNPAMRAIADQME 195
            :|||::.||:::.:|..::.||:....:.:..:.|.||::||.|.:|||:|..||.::.:.:.:|
Human   131 NHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIE 195

  Fly   196 RDEVIRWSSTLPRARVTRWGGMISTPDDALQLMIKRALSESGCPPHILDSLMEFCHERRWPRGLS 260
            .:|::.|.::|..||||||||||||||..||.:|||:|.|||||..|::.|:|..|||.||:||:
Human   196 YNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLA 260

  Fly   261 SLETRQTNRRIYDNYVCRRIPGKQAVLVLSCDNLHMTEDVMIDPGLVMIFAHGIE 315
            :|||||.|||.|:|||.:||||||||:|::|:|.||.:|::.:||||||||||:|
Human   261 TLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVE 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elgi	NP_001261904.1	RING	17..55	CDD:238093	24/37 (65%)
		Sina	83..>157	CDD:302762	38/73 (52%)
		USP8_interact	137..315	CDD:286082	92/177 (52%)
RNF41	NP_001229755.1	mRING-HC-C3HC3D_Nrdp1	15..57	CDD:319548	27/41 (66%)
RNF41	NP_001229755.1	USP8_interact	137..315	CDD:401040	92/177 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2975
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4226
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1892
Isobase	1	0.950	-	0	Normalized mean entropy	S4310
OMA	1	1.010	-	-		QHG48595
OrthoDB	1	1.010	-	-		D422158at33208
OrthoFinder	1	1.000	-	-		FOG0007809
OrthoInspector	1	1.000	-	-		oto91162
orthoMCL	1	0.900	-	-		OOG6_107745
Panther	1	1.100	-	-	LDO	PTHR15315
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5674
SonicParanoid	1	1.000	-	-		X5758
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820