DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GXIVsPLA2 and PLA2G12B

DIOPT Version :9

Sequence 1:	NP_001261903.1	Gene:	GXIVsPLA2 / 39734	FlyBaseID:	FBgn0036545	Length:	230	Species:	Drosophila melanogaster
Sequence 2:	NP_115951.2	Gene:	PLA2G12B / 84647	HGNCID:	18555	Length:	195	Species:	Homo sapiens

Alignment Length:	196	Identity:	60/196 - (30%)
Similarity:	91/196 - (46%)	Gaps:	55/196 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AYSGYGSSTIVHLRDAIIAAEAIFGDVFKNLIVLVRKFRTVHEVFDAAVD----EN--CIYQC-- 75
            :||.:|   :.|||.:                     |.:|:..||:.::    :|  |.|:|
Human    30 SYSDWG---LRHLRGS---------------------FESVNSYFDSFLELLGGKNGVCQYRCRY 70

  Fly    76 ---PAPDIGGPAPRAVQNKFYTP-TADGCGS--LGLRI--STDY-LPAKEMETCCNDHDICYDTC 131
               |.|..|           |.| ..:||||  |||::  |.|. :||  |..|||..|:|||||
Human    71 GKAPMPRPG-----------YKPQEPNGCGSYFLGLKVPESMDLGIPA--MTKCCNQLDVCYDTC 122

  Fly   132 NSDKELCDLDFKRCLYKYCDSYEKSIA-SDLMMKGCKAAAKMLFTGTLTLGCRSYLDSQQRSCYC 195
            .::|..||..|:.||:..|...::|:. ...:...|.:....:|....|||||.:::||:.:|.|
Human   123 GANKYRCDAKFRWCLHSICSDLKRSLGFVSKVEAACDSLVDTVFNTVWTLGCRPFMNSQRAACIC 187

  Fly   196 A 196
            |
Human   188 A 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GXIVsPLA2	NP_001261903.1	Phospholip_A2_3	18..199	CDD:421899	60/196 (31%)
PLA2G12B	NP_115951.2	PLA2G12	12..195	CDD:311102	60/196 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157586
Domainoid	1	1.000	87	1.000	Domainoid score	I8003
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	87	1.000	Inparanoid score	I5144
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1299904at2759
OrthoFinder	1	1.000	-	-		FOG0003743
OrthoInspector	1	1.000	-	-		otm42250
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12824
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5673
SonicParanoid	1	1.000	-	-		X2603
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.990