Protein Alignment Pka-C3 and PKH2

DIOPT Version :10

• Sequence 1: NP_730083.2
• Gene: Pka-C3 / 39733
• FlyBaseID: FBgn0000489
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_014541.1
• Gene: PKH2 / 854053
• SGDID: S000005460
• Length: 1081
• Species: Saccharomyces cerevisiae
• Alignment Length: 479
• Identity: 125/479 - (26%)
• Similarity: 226/479 - (47%)
• Gaps: 72/479 - (15%)

  Fly   115 NTMTSAYKIPS-------NNSTTANDSSNTETTFTFKLGRSNGRSSSNVA----SSESSDPL--- 165
            |:|:....:||       |..|.....|:.:..:..|.......|:.||.    ...::.|:
Yeast     7 NSMSPRPLLPSDEQKLNINLLTKKEKFSHLDPHYDAKATPQRSTSNRNVGDLLLEKRTAKPMIQK 71

  Fly   166 ----ESDYSEEDPEQEQQRPDPAT------NSRSSSTATTTTTSSADHDNDVDEEDEEDDENEGE 220
                ..::.|....|:::..|..|      |..:..  |..:|:...:|||.|..|..|.:
Yeast    72 ALTNTDNFIEMYHNQQRKNLDDDTIKEVMINDENGK--TVASTNDGRYDNDYDNNDINDQK---- 130

  Fly   221 GNGRDADDATHDS---SESIEEDDGN---ETDDEEDDDESEESSSVQTAKGVRKYHLDDYQIIKT 279
                     |.|:   |..:|::...   |.|.......::|||..|  |.:.|..:.|::....
Yeast   131 ---------TLDNIAGSPHMEKNRNKVKIEHDSSSQKPIAKESSKAQ--KNIIKKGIKDFKFGSV 184

  Fly   280 VGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNILREIRH-PFVISLEWSTKD 343
            :|.|.:..|.|.....::|..|.|:|....:||.|::::|..|:..|:::.: |.|:.|..:.:|
Yeast   185 IGDGAYSTVMLATSIDTKKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQD 249

  Fly   344 DSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINRD 408
            :|:||.:.:|...|:..:.::..|......:.:|||:|:.|::||||..|::||:||||:|::.:
Yeast   250 ESSLYFLLEYAPNGDFLSLMKKYGSLDETCARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGE 314

  Fly   409 GHLKITDFGFAK--------------KLRDRTWTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLI 459
            ..:|:||||.||              .|..|:.:..||.||::||::.....:...|.||.|.::
Yeast   315 MKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIWAFGCIL 379

  Fly   460 YEMLVGYPPFYDEQPFGIYEKILSGKIEWERHMDPIAKDLIKKLLVNDRTKRLGNMKNGADDVKR 524
            ::|:.|.|||.....:..::|::..:..:......|.:||:||:||.:..:||     ....:|.
Yeast   380 FQMIAGKPPFKATNEYLTFQKVMKVQYAFTPGFPLIIRDLVKKILVKNLDRRL-----TISQIKE 439

  Fly   525 HRWFKHLNWND--VYSK---KLKP 543
            |.:||.||:.|  |:||   ::||
Yeast   440 HHFFKDLNFKDGSVWSKTPPEIKP 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	88/292 (30%)
PKH2	NP_014541.1	STKc_PDK1	177..443	CDD:270733	78/270 (29%)