Protein Alignment Pka-C3 and RPS6KA3

DIOPT Version :10

• Sequence 1: NP_730083.2
• Gene: Pka-C3 / 39733
• FlyBaseID: FBgn0000489
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: XP_011543857.1
• Gene: RPS6KA3 / 6197
• HGNCID: 10432
• Length: 746
• Species: Homo sapiens
• Alignment Length: 364
• Identity: 127/364 - (34%)
• Similarity: 210/364 - (57%)
• Gaps: 23/364 - (6%)

  Fly   226 ADDATHDSSESIEEDDGNETDDEEDDDESEESSSVQTA------KGVRKYHLDDYQIIKTVGTGT 284
            |.::..||:|:.::.......:||.:.::||.|..:.|      :|..|.....::::|.:|.|:
Human    14 AVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGS 78

  Fly   285 FGRVCLCRDRIS----EKYCAMKILAMTEVIRLKQIEHVKNERNILREIRHPFVISLEWSTKDDS 345
            ||:|.|.: :||    .:..|||:|... .::::.....|.||:||.|:.|||::.|.::.:.:.
Human    79 FGKVFLVK-KISGSDARQLYAMKVLKKA-TLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEG 141

  Fly   346 NLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINRDGH 410
            .||:|.|::.||:|||.|.....||.:...||.||:..||::||||.|:||||||||:|::.:||
Human   142 KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGH 206

  Fly   411 LKITDFGFAKKLRD---RTWTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGYPPFYDE 472
            :|:||||.:|:..|   :.::.|||.||:|||::..:||.::.|||:.|||::|||.|..||..:
Human   207 IKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGK 271

  Fly   473 QPFGIYEKILSGKIEWERHMDPIAKDLIKKLLVNDRTKRL------GNMKNGADDVKRHRWFKHL 531
            ........||..|:...:.:.|.|:.|::.|...:...||      |...:|.:::|||.:|..:
Human   272 DRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLVNPFLIGAGPDGVEEIKRHSFFSTI 336

  Fly   532 NWNDVYSKKLKPPILPDVHHDGDTKNFDDYPEKDWKPAK 570
            :||.:|.:::.||..|......||..||  ||...|..|
Human   337 DWNKLYRREIHPPFKPATGRPEDTFYFD--PEFTAKTPK 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	111/303 (37%)
RPS6KA3	XP_011543857.1	STKc_RSK_N	72..394	CDD:270734	115/306 (38%)
		STKc_RSK2_C	408..737	CDD:271078