Protein Alignment Pka-C3 and lats2

DIOPT Version :10

• Sequence 1: NP_730083.2
• Gene: Pka-C3 / 39733
• FlyBaseID: FBgn0000489
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001116779.2
• Gene: lats2 / 567674
• ZFINID: ZDB-GENE-050119-6
• Length: 1140
• Species: Danio rerio
• Alignment Length: 694
• Identity: 178/694 - (25%)
• Similarity: 275/694 - (39%)
• Gaps: 210/694 - (30%)

  Fly    44 SGLRAGLATPTQRG-----------KATGDNGTTGTPARTIGKP---QARIATAMST-----ATC 89
            |.:..||.||::..           .|.|..||  .|||....|   :.|:.:..::     ...
Zfish   392 SDVPQGLLTPSRASLNLDLYEHHWPGAQGPEGT--PPARQPQGPFRGEVRVPSRTNSFNNHQKVT 454

  Fly    90 ARFCTPLSSGTAGSTSKLTTGNGSGNTMTSAYKIPSNNSTTANDSSNTETTFTFKLGRSNGRSS- 153
            .|...|.::..||   |..:..|..||:|:....|......           :.::.|...:::
Zfish   455 VRQTLPPTASVAG---KPESSLGPPNTITAVTSPPIQPPVK-----------SIRVMRPEPKTAV 505

  Fly   154 -------SNVASSESSDPL----ESDYSEEDPEQEQQRPDP---------------------ATN 186
                   .:..|.|:.|.|    :.:::.| |.||.:.|.|                     |.:
Zfish   506 GPCHPGWLSAQSPEAQDSLGYIPDENFTLE-PSQEHRCPPPPYPKTLLVSGSGPEPASLEPVAMS 569

  Fly   187 SRSSSTATTTTTSSADHDNDVDEEDE---EDDENEGEG-------------------NGRDADDA 229
            .....:||..|..|    :.|.:::|   :|....|:|                   |.||
Zfish   570 GLQDVSATGRTIQS----SSVGKQEESIFKDKVKMGKGEKAVKDKKQIQTSPVPVRKNARD---- 626

  Fly   230 THDSSES-------------IEEDDGN-------------ETDDEEDDDESEESSSVQTAK---- 264
             .:..||             :|:...|             :.:.|.......|:...|..|
Zfish   627 -EEKRESRIKSYSPFAFKFYMEQHVENVMKTYQQKLNRRMQLEQEMSKAGLSEAEQEQMRKMLYQ 690

  Fly   265 ------GVRKYHLDD--YQIIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKN 321
                  .:|:..:|.  :..|||:|.|.||.|||.|...:....|||.|...:|:...|:.|||.
Zfish   691 KESNYNRLRRAKMDKSMFVKIKTLGIGAFGEVCLTRKVDTGALYAMKTLRKKDVLNRNQVAHVKA 755

  Fly   322 ERNILREIRHPFVISLEWSTKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALE 386
            ||:||.|..:.:|:.|.:|.:|..|||.:.||:.||::.:.|...|.|....:.||.||:..|:|
Zfish   756 ERDILAEADNEWVVRLYYSFQDRDNLYFVMDYIPGGDMMSLLIRMGVFPEVLARFYVAELTLAIE 820

  Fly   387 YLHSLQIVYRDLKPENLLINRDGHLKITDFGFAKKLR---------------------------- 423
            .:|.:..::||:||:|:||:.|||:|:||||.....|
Zfish   821 SVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHIRQDSMEPSDFWDDV 885

  Fly   424 ------DRTWTL----------C------GTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGY 466
                  ||..||          |      |||.|||||::..||:.:..|||::||:::|||||.
Zfish   886 SNCRCGDRLMTLEQRATRQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQ 950

  Fly   467 PPFYDEQPFGIYEKILSGKIEWER--------HMDPIAKDLIKKLLVNDRTKRLGNMKNGADDVK 523
            |||....|.....|:    |.||.        .:.|.|.|:|.:|..: ..:|||.  |||.::|
Zfish   951 PPFLAPTPTETQLKV----INWENTLQVPPQVKLSPEAVDIIGQLCCS-AEERLGG--NGAGEIK 1008

  Fly   524 RHRWFKHLNWNDVYSKKLK---PPILPDVHHDGDTKNFDDYPEK 564
            .|.:|..::    :|..|:   .|..|.:.|..||.|||...|:
Zfish  1009 AHPFFSEVD----FSSNLRTQPAPYRPKIAHPMDTSNFDPVEEE 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	120/353 (34%)
lats2	NP_001116779.2	UBA_LATS2	105..145	CDD:270581
		PHA03247	<206..565	CDD:223021	35/189 (19%)
		MobB_LATS2	625..707	CDD:439272	12/86 (14%)
		Protein Kinases, catalytic domain	706..1088	CDD:473864	120/354 (34%)