DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-C3 and prkx

DIOPT Version :9

Sequence 1:	NP_730083.2	Gene:	Pka-C3 / 39733	FlyBaseID:	FBgn0000489	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_690430.2	Gene:	prkx / 561941	ZFINID:	ZDB-GENE-090313-408	Length:	357	Species:	Danio rerio

Alignment Length:	346	Identity:	204/346 - (58%)
Similarity:	261/346 - (75%)	Gaps:	5/346 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 NETDDEEDDDESEESSSVQTAKGV-----RKYHLDDYQIIKTVGTGTFGRVCLCRDRISEKYCAM 302
            ||:....|...:|..|....|...     |.|.|||...|.||||||||||.|.:|:.:..:.|:
Zfish    12 NESSSGRDSGRTEAGSPTLPAGAASLTTNRTYTLDDLDTIATVGTGTFGRVFLVKDKKTRGFFAL 76

  Fly   303 KILAMTEVIRLKQIEHVKNERNILREIRHPFVISLEWSTKDDSNLYMIFDYVCGGELFTYLRNAG 367
            |.:.:.:||||||.:||.||:.:|.|:.|||::.|.|:..||..|||:.:||.|||||:|||:.|
Zfish    77 KAMKIPDVIRLKQEQHVHNEKEVLTEVNHPFLVRLFWTHHDDRFLYMLMEYVNGGELFSYLRSRG 141

  Fly   368 KFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGFAKKLRDRTWTLCGT 432
            .|::.|..||:||||.|:|||||.:||||||||||:|::.:||:::|||||||||.:||||||||
Zfish   142 HFSNSTGMFYSAEIVCAIEYLHSKEIVYRDLKPENILLDSEGHIRLTDFGFAKKLSERTWTLCGT 206

  Fly   433 PEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGYPPFYDEQPFGIYEKILSGKIEWERHMDPIAK 497
            |||:|||:||||||.:|||||||||||:|||.|||||:|:.|||||:|||:||:|:.||:|...|
Zfish   207 PEYLAPEVIQSKGHGRAVDWWALGVLIFEMLAGYPPFFDDNPFGIYQKILAGKLEFPRHLDLYVK 271

  Fly   498 DLIKKLLVNDRTKRLGNMKNGADDVKRHRWFKHLNWNDVYSKKLKPPILPDVHHDGDTKNFDDYP 562
            |||||.||.||.:|||||||||||||:|||||.:||..|..:||||||:|.|.|:|||.|||.||
Zfish   272 DLIKKFLVTDRERRLGNMKNGADDVKKHRWFKSVNWESVPCRKLKPPIVPKVSHEGDTSNFDSYP 336

  Fly   563 EKDWKPAKAVDQRDLQYFNDF 583
            :::||....|..:||:.|.:|
Zfish   337 DEEWKKDTPVPAKDLEIFKNF 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	PTZ00263	262..583	CDD:140289	198/325 (61%)
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	187/290 (64%)
prkx	XP_690430.2	PTZ00263	43..357	CDD:140289	196/313 (63%)
prkx	XP_690430.2	STKc_PRKX_like	46..337	CDD:270763	187/290 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595135
Domainoid	1	1.000	368	1.000	Domainoid score	I870
eggNOG	1	0.900	-	-		E1_KOG0616
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55868
Inparanoid	1	1.050	444	1.000	Inparanoid score	I1616
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D277423at33208
OrthoFinder	1	1.000	-	-		FOG0000539
OrthoInspector	1	1.000	-	-		oto38999
orthoMCL	1	0.900	-	-		OOG6_100326
Panther	1	1.100	-	-	LDO	PTHR24353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4097
SonicParanoid	1	1.000	-	-		X4144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790