DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pka-C3 and PRKG2

DIOPT Version :10

Sequence 1:NP_730083.2 Gene:Pka-C3 / 39733 FlyBaseID:FBgn0000489 Length:583 Species:Drosophila melanogaster
Sequence 2:NP_006250.1 Gene:PRKG2 / 5593 HGNCID:9416 Length:762 Species:Homo sapiens


Alignment Length:453 Identity:153/453 - (33%)
Similarity:240/453 - (52%) Gaps:47/453 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   163 DPLESDYSEEDPEQEQQRPDPATNSRSSSTATTTTTSSADHDNDVDEEDEEDDENEGE-----GN 222
            |.||.:|.::.....::..:.:|....:......|.|:..||.....:..:..|..||     .:
Human   300 DCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDD 364

  Fly   223 GRDADDATHDSSES---IEEDDGNET--------------------DDEEDDDESEESS------ 258
            .|.|:....::..:   |:.:..|:|                    |||:...:...|:      
Human   365 VRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKA 429

  Fly   259 ----SVQTAKGVRKYH----LDDYQIIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQ 315
                .:|..:.|.::.    ..:.:||.|:|.|.||||.|.:.:......|||.:....::..||
Human   430 LSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQ 494

  Fly   316 IEHVKNERNILREIRHPFVISLEWSTKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAE 380
            .|||.:|:.||.|:..||::.|..:.||:..:||:.:...||||::.||:.|.|...||.|..|.
Human   495 QEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVAC 559

  Fly   381 IVSALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGFAKKL--RDRTWTLCGTPEYIAPEIIQS 443
            :..|.:|||.|.|:|||||||||:::.:|:||:.|||||||:  ..:|||.||||||:|||:|.:
Human   560 VTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILN 624

  Fly   444 KGHNKAVDWWALGVLIYEMLVGYPPFYDEQPFGIYEKILSG--KIEWERHMDPIAKDLIKKLLVN 506
            |||:.:||:|:||:|:||:|.|.|||........|..||.|  |:::.|.:....:|||::|...
Human   625 KGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQ 689

  Fly   507 DRTKRLGNMKNGADDVKRHRWFKHLNWNDVYSKKLKPPILPDVHHDGDTKNFDDY-PEKDWKP 568
            :.|:||||:|||.:|:|:|||....||..:.::.|..|:..::....|...||.| |||...|
Human   690 NPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPP 752

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pka-C3NP_730083.2 STKc_PRKX_like 272..563 CDD:270763 126/295 (43%)
PRKG2NP_006250.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 117..138
cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000305|PubMed:26769964 168..283
CAP_ED 168..277 CDD:237999
cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000305|PubMed:26769964 286..416 20/115 (17%)
CAP_ED 286..401 CDD:237999 17/100 (17%)
STKc_cGK 459..718 CDD:270724 117/258 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 740..762 7/13 (54%)
Blue background indicates that the domain is not in the aligned region.

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