Protein Alignment Pka-C3 and PRKCZ

DIOPT Version :10

• Sequence 1: NP_730083.2
• Gene: Pka-C3 / 39733
• FlyBaseID: FBgn0000489
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: XP_016857278.1
• Gene: PRKCZ / 5590
• HGNCID: 9412
• Length: 603
• Species: Homo sapiens
• Alignment Length: 366
• Identity: 116/366 - (31%)
• Similarity: 196/366 - (53%)
• Gaps: 49/366 - (13%)

  Fly   209 EEDEEDDENEGEGNGRDADDATHDSSESIEEDDG-------NETDDEEDDDES-----EESSSVQ 261
            :|...||:||      |||..:       ||.||       .:.|..:||.|.     :....::
Human   191 QEPPVDDKNE------DADLPS-------EETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIK 242

  Fly   262 TAKGVRKYHLDDYQIIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNIL 326
            .::|:   .|.|:.:|:.:|.|::.:|.|.|.:.:::..|||::....|...:.|:.|:.|:::.
Human   243 ISQGL---GLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVF 304

  Fly   327 REI-RHPFVISLEWSTKDDS--------NLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIV 382
            .:. .:||::.|....:..|        .|:::.:||.||:|..:::...|...:.:.||||||.
Human   305 EQASSNPFLVGLHSCFQTTSRLRRLSPCRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEIC 369

  Fly   383 SALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGFAKK---LRDRTWTLCGTPEYIAPEIIQSK 444
            .||.:||...|:|||||.:|:|::.|||:|:||:|..|:   ..|.|.|.||||.||||||::.:
Human   370 IALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 434

  Fly   445 GHNKAVDWWALGVLIYEMLVGYPPF---YDEQPFG----IYEKILSGKIEWERHMDPIAKDLIKK 502
            .:..:|||||||||::||:.|..||   .|.....    :::.||...|...|.:...|..::|.
Human   435 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKG 499

  Fly   503 LLVNDRTKRLG-NMKNGADDVKRHRWFKHLNWNDVYSKKLK 542
            .|..|..:||| ..:.|..|:|.|.:|:.::| |:..::|:
Human   500 FLNKDPKERLGCRPQTGFSDIKSHAFFRSIDW-DLMHRQLR 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	98/291 (34%)
PRKCZ	XP_016857278.1	PB1_aPKC	16..98	CDD:99725
		C1	129..183	CDD:412127
		Protein Kinases, catalytic domain	236..537	CDD:473864	99/304 (33%)