DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pka-C3 and PKN2

DIOPT Version :10

Sequence 1:NP_730083.2 Gene:Pka-C3 / 39733 FlyBaseID:FBgn0000489 Length:583 Species:Drosophila melanogaster
Sequence 2:NP_006247.1 Gene:PKN2 / 5586 HGNCID:9406 Length:984 Species:Homo sapiens


Alignment Length:451 Identity:133/451 - (29%)
Similarity:239/451 - (52%) Gaps:55/451 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 ASSESSDPLESDYSEEDPEQEQQRPDPATNSRSSSTATTTTTSSADHDNDVDEEDEEDDENEGEG 221
            ||..:...|:.|...|.|      |.|   .|:||               :.|.||..:....:.
Human   558 ASDSTVTKLDFDLEPEPP------PAP---PRASS---------------LGEIDESSELRVLDI 598

  Fly   222 NGRDAD---DATHDSSESIEEDDGNETDDEEDDDESE-ESSSVQTAKGVR-----KYHLDDYQII 277
            .|:|::   |..:|.:..:.:   ::::.:.|..:|. |.|.:|..:..|     :::|.|::..
Human   599 PGQDSETVFDIQNDRNSILPK---SQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCC 660

  Fly   278 KTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNI---LREIRHPFVISLEW 339
            ..:|.|.||:|.|...:.:.:..|:|.|...:::...:::.:..|:.|   :..:||||:::|..
Human   661 AVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFA 725

  Fly   340 STKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLL 404
            ..:...::..:.:|..||:|..:: :...|:...:.||||.:|..|:|||..:|||||||.:|||
Human   726 CFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLL 789

  Fly   405 INRDGHLKITDFGFAKK---LRDRTWTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGY 466
            ::.:|.:||.|||..|:   ..|||.|.|||||::|||::....:.:|||||.|||||||||||.
Human   790 LDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGE 854

  Fly   467 PPFYDEQPFGIYEKILSGKIEWERHMDPIAKDLIKKLLVNDRTKRLGNMKNGADDVKRHRWFKHL 531
            .||..:....:::.|::.::.:.|.:...|..::::||..:..:|||..:..|:|||:|.:|:.:
Human   855 SPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLI 919

  Fly   532 NWNDVYSKKLKPPILPDVHHDGDTKNFDD---------YPEKDWKPAKAVDQRDLQYFNDF 583
            :|:.:..||:|||.:|.:....|..||||         .|.::   .:.:.:.:.:.|.||
Human   920 DWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPRE---PRILSEEEQEMFRDF 977

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pka-C3NP_730083.2 STKc_PRKX_like 272..563 CDD:270763 104/305 (34%)
PKN2NP_006247.1 HR1_PKN_1 42..107 CDD:212012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..133
HR1 130..201 CDD:469609
HR1_PKN2_3 209..282 CDD:212025
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 351..383
Necessary to rescue apical junction formation. /evidence=ECO:0000250 382..463
C2_PKN-like 390..473 CDD:176069
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 558..584 11/49 (22%)
STKc_PKN 657..982 CDD:270741 107/325 (33%)
Necessary for the catalytic activity 917..977 14/62 (23%)
Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA 978..984 133/451 (29%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.