Protein Alignment Pka-C3 and PRKCH

DIOPT Version :10

• Sequence 1: NP_730083.2
• Gene: Pka-C3 / 39733
• FlyBaseID: FBgn0000489
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: XP_047287541.1
• Gene: PRKCH / 5583
• HGNCID: 9403
• Length: 782
• Species: Homo sapiens
• Alignment Length: 337
• Identity: 114/337 - (33%)
• Similarity: 190/337 - (56%)
• Gaps: 8/337 - (2%)

  Fly   253 ESEESSSVQTAKGV---RKYHLDDYQIIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLK 314
            :.:|||......||   .:..:|:::.|:.:|.|:||:|.|.|.:.:....|:|:|....:::..
Human   430 QGKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDD 494

  Fly   315 QIEHVKNERNILREIR-HPFVISLEWSTKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYA 378
            .:|....|:.||...| |||:..|....:....|:.:.::|.||:|..:::.:.:|....:.|||
Human   495 DVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYA 559

  Fly   379 AEIVSALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGFAKK---LRDRTWTLCGTPEYIAPEI 440
            |||:|||.:||...|:|||||.:|:|::.:||.|:.|||..|:   ....|.|.||||:||||||
Human   560 AEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEI 624

  Fly   441 IQSKGHNKAVDWWALGVLIYEMLVGYPPFYDEQPFGIYEKILSGKIEWERHMDPIAKDLIKKLLV 505
            :|...:..||||||:|||:||||.|:.||..|....::|.||:.::.:...:...|..::|..:.
Human   625 LQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT 689

  Fly   506 NDRTKRLGNMKNGADD-VKRHRWFKHLNWNDVYSKKLKPPILPDVHHDGDTKNFDDYPEKDWKPA 569
            .:.|.|||::..|.:. :.||.:||.::|..:..::::||..|.:....|..|||....|:....
Human   690 KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVL 754

  Fly   570 KAVDQRDLQYFN 581
            ..:|:..|...|
Human   755 TPIDEGHLPMIN 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	105/295 (36%)
PRKCH	XP_047287541.1	C2_PKC_epsilon	8..122	CDD:175981
		C1_nPKC_epsilon-like_rpt1	265..325	CDD:410385
		C1_nPKC_epsilon-like_rpt2	343..397	CDD:410388
		STKc_nPKC_eta	458..780	CDD:270742	107/309 (35%)