DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pka-C3 and PRKCE

DIOPT Version :10

Sequence 1:NP_730083.2 Gene:Pka-C3 / 39733 FlyBaseID:FBgn0000489 Length:583 Species:Drosophila melanogaster
Sequence 2:NP_005391.1 Gene:PRKCE / 5581 HGNCID:9401 Length:737 Species:Homo sapiens


Alignment Length:457 Identity:145/457 - (31%)
Similarity:231/457 - (50%) Gaps:54/457 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   144 KLGRSNGRSSSNVASSESSDPLE-SDYSEEDPEQEQQRPDPATNSRSSSTATTTTTSSADHDNDV 207
            |:..|..|....:|.:||..|.. |..||||              ||.|..|          :..
Human   312 KITNSGQRRKKLIAGAESPQPASGSSPSEED--------------RSKSAPT----------SPC 352

  Fly   208 DEEDEEDDENEGEGNGRDADDATHDSSESIEEDDGNETDDEEDDDESEESSSVQTAKGVRKYHLD 272
            |:|.:|.:.|..:....|.....|.::.|   .||......|:.:..:..:        ::..||
Human   353 DQEIKELENNIRKALSFDNRGEEHRAASS---PDGQLMSPGENGEVRQGQA--------KRLGLD 406

  Fly   273 DYQIIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNILREIR-HPFVIS 336
            ::..||.:|.|:||:|.|...:..::..|:|:|....:::...::....|:.||...| ||::..
Human   407 EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQ 471

  Fly   337 LE--WSTKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLK 399
            |.  :.|||  .|:.:.:||.||:|...::.:.||....|.|||||:.|||.:||...::|||||
Human   472 LYCCFQTKD--RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLK 534

  Fly   400 PENLLINRDGHLKITDFGFAKK--LRD-RTWTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYE 461
            .:|:|::.:||.|:.|||..|:  |.. .|.|.||||:||||||:|...:..:|||||||||:||
Human   535 LDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYE 599

  Fly   462 MLVGYPPFYDEQPFGIYEKILSGKIEWERHMDPIAKDLIKKLLVNDRTKRLGNM--KNGADDVKR 524
            |:.|.|||..:....::|.||...:.:...:...|..::|..:..:..||||.:  :||.|.:|:
Human   600 MMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQ 664

  Fly   525 HRWFKHLNWNDVYSKKLKPPILPDVHHDGDTKNFD-DYPEK-------DWKPAKAVDQRDLQYFN 581
            |.:||.::|..:..||:|||..|.:....|..||| |:..:       |....|.::|.:.:.|:
Human   665 HPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFS 729

  Fly   582 DF 583
            .|
Human   730 YF 731

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pka-C3NP_730083.2 STKc_PRKX_like 272..563 CDD:270763 113/299 (38%)
PRKCENP_005391.1 C2_PKC_epsilon 3..135 CDD:175981
C1_nPKC_epsilon-like_rpt1 161..224 CDD:410385
Interaction with actin. /evidence=ECO:0000250 223..228
C1_nPKC_epsilon-like_rpt2 241..295 CDD:410388
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 325..356 14/54 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..398 6/30 (20%)
STKc_nPKC_epsilon 412..732 CDD:270743 116/322 (36%)
Blue background indicates that the domain is not in the aligned region.

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