Protein Alignment Pka-C3 and PRKACB

DIOPT Version :10

• Sequence 1: NP_730083.2
• Gene: Pka-C3 / 39733
• FlyBaseID: FBgn0000489
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_891993.1
• Gene: PRKACB / 5567
• HGNCID: 9381
• Length: 398
• Species: Homo sapiens
• Alignment Length: 369
• Identity: 177/369 - (47%)
• Similarity: 254/369 - (68%)
• Gaps: 11/369 - (2%)

  Fly   224 RDADDATHDSSESIEEDDGNETDDEEDDDESEESSSVQTAKG-VRKYH--------LDDYQIIKT 279
            |.:....||...::|.|..:.::.....|.|.:....:..:. ::|:.        |:|::..||
Human    32 RHSKGTAHDQKTALENDSLHFSEHTALWDRSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKT 96

  Fly   280 VGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNILREIRHPFVISLEWSTKDD 344
            :|||:||||.|.:.:.:|:|.|||||...:|::||||||..||:.||:.:..||::.||::.||:
Human    97 LGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDN 161

  Fly   345 SNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINRDG 409
            |||||:.:||.|||:|::||..|:|:...:.||||:||...||||||.::|||||||||||:..|
Human   162 SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQG 226

  Fly   410 HLKITDFGFAKKLRDRTWTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGYPPFYDEQP 474
            ::::|||||||:::.|||||||||||:|||||.|||:||||||||||||||||..|||||:.:||
Human   227 YIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQP 291

  Fly   475 FGIYEKILSGKIEWERHMDPIAKDLIKKLLVNDRTKRLGNMKNGADDVKRHRWFKHLNWNDVYSK 539
            ..|||||:|||:.:..|.....|||::.||..|.|||.||:|||..|:|.|:||...:|..:|.:
Human   292 IQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQR 356

  Fly   540 KLKPPILPDVHHDGDTKNFDDYPEKDWKPAKAVDQRDLQYFNDF 583
            |::.|.:|.....|||.|||||.|:|.:  .::.::..:.|.:|
Human   357 KVEAPFIPKFRGSGDTSNFDDYEEEDIR--VSITEKCAKEFGEF 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	164/290 (57%)
PRKACB	NP_891993.1	STKc_PKA	89..378	CDD:271111	162/288 (56%)