Protein Alignment Pka-C3 and Lats2

DIOPT Version :10

• Sequence 1: NP_730083.2
• Gene: Pka-C3 / 39733
• FlyBaseID: FBgn0000489
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_056586.2
• Gene: Lats2 / 50523
• MGIID: 1354386
• Length: 1042
• Species: Mus musculus
• Alignment Length: 756
• Identity: 185/756 - (24%)
• Similarity: 278/756 - (36%)
• Gaps: 275/756 - (36%)

  Fly    52 TP----TQRGKATGDNGTTGTPARTIGKPQARIATAMSTATCARFCTPLSS------GTAGSTSK 106
            ||    :...||.|     |.||.......|.:.||......|   ||..:      ||.|.|.
Mouse   267 TPPDAYSSMAKAQG-----GPPASLTFPAHAGLYTASHHKPAA---TPPGAHPLHVLGTRGPTF- 322

  Fly   107 LTTGNGSGNTMTSAYKIPSNNSTTANDSSNTETTFTFKLGRSNGRSSSNVASSES--SDPLESD- 168
                  :|.:...|...||.||..|:         .::||.:...|::.:|..:|  ...||:.
Mouse   323 ------TGESSAQAVLAPSRNSLNAD---------LYELGSTVPWSAAPLARRDSLQKQGLEASR 372

  Fly   169 ------------YSEEDPEQEQQ-------------------------RPDPAT----------- 185
                        .|..:|:.|..                         ||:|.|
Mouse   373 PHVAFRAGPSRTNSFNNPQPEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVA 437

  Fly   186 --NSRSSSTATTTTTSSADHDNDVD---------------------------------------- 208
              .:.::.:..|...|:..|..|||
Mouse   438 APTAPATESLETKEGSAGPHPLDVDYGGSERRCPPPPYPKHLLLPSKSEQYSVDLDSLCTSVQQS 502

  Fly   209 -----EEDEEDDENEG-EGN--GRDADDATHDSSESIEEDDGNETDDEEDDDESEESSSVQTAKG 265
                 |:|..|..::| :|:  |||... ...|...:.::    :.|||..:...:|.|....|.
Mouse   503 LRGGTEQDRSDKSHKGAKGDKAGRDKKQ-IQTSPVPVRKN----SRDEEKRESRIKSYSPYAFKF 562

  Fly   266 VRKYHLDD------------------------------------YQ------------------- 275
            ..:.|:::                                    ||
Mouse   563 FMEQHVENVIKTYQQKVSRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFV 627

  Fly   276 IIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNILREIRHPFVISLEWS 340
            .|||:|.|.||.|||.....:....|||.|...:|:...|:.|||.||:||.|..:.:|:.|.:|
Mouse   628 KIKTLGIGAFGEVCLACKLDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYS 692

  Fly   341 TKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLI 405
            .:|..:||.:.||:.||::.:.|.....|....:.||.||:..|:|.:|.:..::||:||:|:||
Mouse   693 FQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILI 757

  Fly   406 NRDGHLKITDFGFAKKLRDRTWT------------------------------------------ 428
            :.|||:|:||||.....|   ||
Mouse   758 DLDGHIKLTDFGLCTGFR---WTHNSKYYQKGNHMRQDSMEPGDLWDDVSNCRCGDRLKTLEQRA 819

  Fly   429 -----------LCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGYPPFYDEQPFGIYEKIL 482
                       |.|||.|||||::..||:.:..|||::||:::|||||.|||....|.....|:
Mouse   820 QKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKV- 883

  Fly   483 SGKIEWER--------HMDPIAKDLIKKLLVNDRTKRLGNMKNGADDVKRHRWFKHLNWN-DVYS 538
               |.||.        .:...|:|||.||.. ....|||  ::||||:|.|.:|..:::: |:
Mouse   884 ---INWESTLHIPTQVRLSAEARDLITKLCC-AADCRLG--RDGADDLKAHPFFNTIDFSRDI-- 940

  Fly   539 KKLKPPILPDVHHDGDTKNFDDYPEKD-W-----KPAKAVD 573
            :|...|.:|.:.|..||.|||...|:. |     :.|||.|
Mouse   941 RKQPAPYVPTISHPMDTSNFDPVDEESPWHEASGESAKAWD 981

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	118/407 (29%)
Lats2	NP_056586.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..44
		Interaction with ubiquitinated AMOTL2. /evidence=ECO:0000250|UniProtKB:Q9NRM7	100..140
		UBA_LATS2	100..140	CDD:270581
		PHA03247	<150..513	CDD:223021	47/269 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	237..282		5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..399		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	442..481		6/38 (16%)
		PPxY motif	472..475		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..550		12/53 (23%)
		MobB_LATS2	543..625	CDD:439272	9/81 (11%)
		Protein Kinases, catalytic domain	624..1004	CDD:473864	122/370 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1014..1042