DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-C3 and Prkx

DIOPT Version :9

Sequence 1:	NP_730083.2	Gene:	Pka-C3 / 39733	FlyBaseID:	FBgn0000489	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001029135.1	Gene:	Prkx / 501563	RGDID:	1564076	Length:	358	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	199/352 - (56%)
Similarity:	266/352 - (75%)	Gaps:	2/352 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 SESIEEDDGNETDDEEDDDESEESSS--VQTAKGVRKYHLDDYQIIKTVGTGTFGRVCLCRDRIS 296
            :|:..:|......|..|...|..::.  .:|:.....:.|.|:..|.||||||||||.|.:::..
  Rat     7 AEAAVKDPAARDHDPVDAKISAPAADPLPRTSSQKEGHSLQDWDTIATVGTGTFGRVNLVKEKTG 71

  Fly   297 EKYCAMKILAMTEVIRLKQIEHVKNERNILREIRHPFVISLEWSTKDDSNLYMIFDYVCGGELFT 361
            .:|||:||:::.:||||||.:||:||:.:|:||.|||:|.|.|:..|:..|||:.::|.||||||
  Rat    72 RRYCALKIMSIPDVIRLKQEQHVQNEKAVLKEINHPFLIKLLWTDHDNRFLYMLMEFVPGGELFT 136

  Fly   362 YLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGFAKKLRDRT 426
            ||||.|:|:|..:.|||.|||.|:|||||.:||||||||||:|::|:||:|:|||||||||.|||
  Rat   137 YLRNRGRFSSVAAIFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAKKLVDRT 201

  Fly   427 WTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGYPPFYDEQPFGIYEKILSGKIEWERH 491
            |||||||||:|||:||||||.:||||||||:||:|||.|:|||:|:.|||||:|||:.||::.|.
  Rat   202 WTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILACKIDFPRQ 266

  Fly   492 MDPIAKDLIKKLLVNDRTKRLGNMKNGADDVKRHRWFKHLNWNDVYSKKLKPPILPDVHHDGDTK 556
            :|..:|||||||||.|||:|||||||||:|:||||||:.:.|..|..:||||||:|.:..|||..
  Rat   267 LDFTSKDLIKKLLVVDRTRRLGNMKNGAEDIKRHRWFRGVEWESVPQRKLKPPIVPKLSSDGDIS 331

  Fly   557 NFDDYPEKDWKPAKAVDQRDLQYFNDF 583
            ||:.|||.:.....:|...||:.|.:|
  Rat   332 NFETYPEGELDKTPSVSDEDLETFKNF 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	PTZ00263	262..583	CDD:140289	193/320 (60%)
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	185/290 (64%)
Prkx	NP_001029135.1	PTZ00263	35..358	CDD:140289	193/322 (60%)
Prkx	NP_001029135.1	STKc_PRKX_like	47..338	CDD:270763	185/290 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353083
Domainoid	1	1.000	374	1.000	Domainoid score	I849
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55868
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1679
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D277423at33208
OrthoFinder	1	1.000	-	-		FOG0000539
OrthoInspector	1	1.000	-	-		oto97124
orthoMCL	1	0.900	-	-		OOG6_100326
Panther	1	1.100	-	-	LDO	PTHR24353
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900