Protein Alignment Pka-C3 and Pdk1

DIOPT Version :10

• Sequence 1: NP_730083.2
• Gene: Pka-C3 / 39733
• FlyBaseID: FBgn0000489
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_728471.2
• Gene: Pdk1 / 38017
• FlyBaseID: FBgn0020386
• Length: 836
• Species: Drosophila melanogaster
• Alignment Length: 635
• Identity: 145/635 - (22%)
• Similarity: 255/635 - (40%)
• Gaps: 152/635 - (23%)

  Fly    43 ASGLRAG--LATPTQRGKATGDNGTTGTPARTIGKPQARIATAMSTATCARFCTPLSSGTAGSTS 105
            |||:.|.  :...:..|:....|||         :.|.....|.:|||.|...|  ....|...:
  Fly    37 ASGIAAAAVITVASDCGENCSSNGT---------EHQQHFNIATTTATSATEAT--MPAMAKEKA 90

  Fly   106 KLTTGNGSGN-----------TMTSAYKI-PSNNSTTANDSSNTETTFTFKLGRS----NGRSSS 154
            ..|...|..|           .:.:|.:: ...|.......|:||.....:.|.|    ||.:|
  Fly    91 SATVSLGESNFRDINLKDLAVVVEAASRLHHQQNVCGCGAVSSTENNNNSRYGSSKYLTNGHTS- 154

  Fly   155 NVASSESSDPLESDYSEEDPEQEQQRPDPATNSRSSSTATTT------TTSSADHDNDVDEEDEE 213
                     ||.:                |..|.|||.|||.      ..|...:.||:.::.|.
  Fly   155 ---------PLAA----------------AVASNSSSVATTPHCRMLHNCSLQQYQNDIRQQTEI 194

  Fly   214 DD---ENEGEGNGRDADDATHDSSESIEEDDGNETDDEEDDDESEESSSVQTAKGVRKYHLDDYQ 275
            .|   :...:|.          .|:..::....:.:.::..::|::...:|.....|.  .:|:.
  Fly   195 LDMLRQQHQQGY----------QSQQQQQQPQQQQEQQQQQEQSQQQQQLQNPAPRRS--PNDFI 247

  Fly   276 IIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNILREIRH-PFVISLEW 339
            ..:.:|.|::..|.|..|..|.:..|:|:.....::|.::.:::|.||.::.::.: |..::|..
  Fly   248 FGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSC 312

  Fly   340 STKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLL 404
            :.:|..:||.:..|...|::..|:...|.|....:..||||::.|.|::|...:|:|||||||:|
  Fly   313 TFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENIL 377

  Fly   405 INRDGHLKITDFGFAKKL----------------------------------------------- 422
            ::.|.|..|.|||.||.:
  Fly   378 LDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDD 442

  Fly   423 ---------------------RDRTWTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGY 466
                                 |.|..:..||.:|::||::|:.....|.|.||||.::|:|:.|.
  Fly   443 GDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGL 507

  Fly   467 PPFYDEQPFGIYEKILSGKIEWERHMDPIAKDLIKKLLVNDRTKRLGNMKNGA--DDVKRHRWFK 529
            |||.....:.|:::||...:::.:..|..|:||::|||..|...|||......  :.::.|.:|.
  Fly   508 PPFRGSNDYVIFKEILDCAVDFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFA 572

  Fly   530 HLNWNDVYSKKLKP--PILPDVHHDGDTKNFDDYPEKDWKPAKAVDQRDL 577
            .::|..:..:...|  |.||.|..|.|.::....| .|.:|  .:|:|.:
  Fly   573 GIDWQTLRQQTPPPIYPYLPGVSQDEDFRSSYTVP-GDLEP--GLDERQI 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	91/363 (25%)
Pdk1	NP_728471.2	STKc_PDK1	244..571	CDD:270733	82/326 (25%)
		PH_PDK1	658..764	CDD:241293