DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-C3 and prkg3

DIOPT Version :9

Sequence 1:	NP_730083.2	Gene:	Pka-C3 / 39733	FlyBaseID:	FBgn0000489	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_017208033.2	Gene:	prkg3 / 326020	ZFINID:	ZDB-GENE-030131-4745	Length:	745	Species:	Danio rerio

Alignment Length:	333	Identity:	139/333 - (41%)
Similarity:	205/333 - (61%)	Gaps:	5/333 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 ESIE-EDDGNETDDEEDDDESEESSSVQTAKGVR-KYHLDDYQ-IIKTVGTGTFGRVCLCRDRIS 296
            ||:| .||.|.::.:|..:::...:|::....|. .|....|| ...|:|.|.||:|.|......
Zfish   396 ESLELHDDANVSEIDEKPEKARPETSLKLKDLVPVLYQEGSYQGDPVTLGIGGFGKVELVTTLEH 460

  Fly   297 EKYCAMKILAMTEVIRLKQIEHVKNERNILREIRHPFVISLEWSTKDDSNLYMIFDYVCGGELFT 361
            .||.|||.::...|:..||..|:..|:.||:.||..|::.|..:.||...:|||.::..|||::|
Zfish   461 RKYFAMKRISKQHVVAKKQEAHILLEKKILQAIRCDFIVRLHAAFKDSRYVYMIMEFCPGGEIWT 525

  Fly   362 YLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGFAKKLR--D 424
            .|:.||:|..:.:.|..|.:|.|..|||:..|:|||||||||:::..|::|:.||||||:|.  :
Zfish   526 KLKEAGRFEEKIAVFITACVVEAYAYLHNKGILYRDLKPENLMLDSKGYVKLVDFGFAKELSRGE 590

  Fly   425 RTWTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGYPPFYDEQPFGIYEKILSGKIEWE 489
            :|::.|||||||:|||||::||:.|.|:|:|||||||:|||.|||...:|..||.|||.|.:.:.
Zfish   591 KTYSFCGTPEYISPEIIQNQGHDIAADFWSLGVLIYELLVGSPPFSSSEPQKIYAKILDGVLNFP 655

  Fly   490 RHMDPIAKDLIKKLLVNDRTKRLGNMKNGADDVKRHRWFKHLNWNDVYSKKLKPPILPDVHHDGD 554
            .:|...||.:|.||......:||||.|||..||:.||||..:||:.:...:|:.|.:..:.....
Zfish   656 SYMGEGAKSIISKLCRLRPGQRLGNTKNGIKDVRHHRWFNSINWHKLRMGQLEAPTVRLIRKGPC 720

  Fly   555 TKNFDDYP 562
            ..|||.:|
Zfish   721 YINFDRFP 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	PTZ00263	262..583	CDD:140289	131/305 (43%)
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	129/294 (44%)
prkg3	XP_017208033.2	CAP_ED	173..282	CDD:237999
		CAP_ED	292..393	CDD:237999
		STKc_cGK	444..699	CDD:270724	118/254 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910