DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pka-C3 and pka1

DIOPT Version :9

Sequence 1:	NP_730083.2	Gene:	Pka-C3 / 39733	FlyBaseID:	FBgn0000489	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_595159.1	Gene:	pka1 / 2539781	PomBaseID:	SPBC106.10	Length:	512	Species:	Schizosaccharomyces pombe

Alignment Length:	529	Identity:	184/529 - (34%)
Similarity:	282/529 - (53%)	Gaps:	73/529 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 GSTSKLTTGNGSGNTMTSAYKIPSNNSTTANDSSNTET--TFTFKLGRSNGRSS--SNVASSESS 162
            |||:   .|:.:....|||...||.|:.:.|:.|..:.  |.:|     ||:.|  .:|.|..|.
pombe    10 GSTN---VGSSTDTLSTSASLHPSMNAGSVNEYSEQQRHGTNSF-----NGKPSVHDSVGSDASV 66

  Fly   163 DPLESDYSEE-----------DPEQEQQRPDPATNSRSSSTATTTTTSSADHDNDVDEEDEEDDE 216
            ....::::|.           :...:.::||...::.:|..|:..:....:.||.:.....|
pombe    67 SNGHNNHNESSLWTSGIPKALEEATKSKKPDSLVSTSTSGCASAHSVGYQNIDNLIPSPLPE--- 128

  Fly   217 NEGEGNGRDADDATHDSSESIEEDDGNETDDEEDDDESEESSSVQTAKGVR-------------- 267
                       .|:..||:|..:....:...|...:..|..|::.   |:|
pombe   129 -----------SASRSSSQSSHQRHSRDGRGELGSEHGERRSAMD---GLRDRHIRKVRVSQLLD 179

  Fly   268 ---------------KYHLDDYQIIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIE 317
                           :|.:.|:..::|:|||:||||.|.:...:..|.|:|:|...:::.:||||
pombe   180 LQRRRIRPADHTTKDRYGIQDFNFLQTLGTGSFGRVHLVQSNHNRLYYAIKVLEKKKIVDMKQIE 244

  Fly   318 HVKNERNILREIRHPFVISLEWST-KDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEI 381
            |..:||.||..::||| |::.|.| :|..||:|:.|:..|||||:.||...:|..:.:.|||||:
pombe   245 HTCDERYILSRVQHPF-ITILWGTFQDAKNLFMVMDFAEGGELFSLLRKCHRFPEKVAKFYAAEV 308

  Fly   382 VSALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGFAKKL-RDRTWTLCGTPEYIAPEIIQSKG 445
            :.||:|||..|||||||||||||::|.|||||.||||||:: .....||||||:|:|||||..|.
pombe   309 ILALDYLHHNQIVYRDLKPENLLLDRFGHLKIVDFGFAKRVSTSNCCTLCGTPDYLAPEIISLKP 373

  Fly   446 HNKAVDWWALGVLIYEMLVGYPPFYDEQPFGIYEKILSGKIEWERHMDPIAKDLIKKLLVNDRTK 510
            :|||.|||:||:||:|||.||||||.|.|..:||.||.||:.:..:..|.:.||:..||..|.|.
pombe   374 YNKAADWWSLGILIFEMLAGYPPFYSENPMKLYENILEGKVNYPSYFSPASIDLLSHLLQRDITC 438

  Fly   511 RLGNMKNGADDVKRHRWFKHLNWNDVYSKKLKPPILPDVHHD-GDTKNFDDYPEKDWKPAKAVDQ 574
            |.||:|:|:.|:..|.||:.::|:.:.::|::.|.:|.:... ||:..||.|.:.......:.|.
pombe   439 RYGNLKDGSMDIIMHPWFRDISWDKILTRKIEVPYVPPIQAGMGDSSQFDAYADVATDYGTSEDP 503

  Fly   575 RDLQYFNDF 583
            .....|.||
pombe   504 EFTSIFKDF 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	PTZ00263	262..583	CDD:140289	147/352 (42%)
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	142/293 (48%)
pka1	NP_595159.1	STKc_PKA_like	199..490	CDD:270732	141/291 (48%)
pka1	NP_595159.1	S_TKc	201..456	CDD:214567	130/255 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	300	1.000	Domainoid score	I258
eggNOG	1	0.900	-	-		E1_KOG0616
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	333	1.000	Inparanoid score	I510
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000539
OrthoInspector	1	1.000	-	-		otm47256
orthoMCL	1	0.900	-	-		OOG6_100326
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.720