Protein Alignment Pka-C3 and AKT1

DIOPT Version :10

• Sequence 1: NP_730083.2
• Gene: Pka-C3 / 39733
• FlyBaseID: FBgn0000489
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_005154.2
• Gene: AKT1 / 207
• HGNCID: 391
• Length: 480
• Species: Homo sapiens
• Alignment Length: 442
• Identity: 148/442 - (33%)
• Similarity: 232/442 - (52%)
• Gaps: 37/442 - (8%)

  Fly   171 EEDPEQEQQRPDPATNSRSSSTATTTT---------------TSSADHDNDVDEEDEEDDENEGE 220
            :|.|:...||..|..|...:......|               |:..:....|:..:|.::
Human    39 KERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREE----- 98

  Fly   221 GNGRDADDATHDSSESIEEDDGNETDDEEDDDESEESSSVQTAKGVRKYHLDDYQIIKTVGTGTF 285
              ...|.....|..:..||::.:.......|:...|...|..||...:..:::::.:|.:|.|||
Human    99 --WTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTF 161

  Fly   286 GRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNILREIRHPFVISLEWSTKDDSNLYMI 350
            |:|.|.:::.:.:|.|||||....::...::.|...|..:|:..||||:.:|::|.:....|..:
Human   162 GKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFV 226

  Fly   351 FDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHS-LQIVYRDLKPENLLINRDGHLKIT 414
            .:|..|||||.:|.....|:...:.||.|||||||:|||| ..:||||||.|||::::|||:|||
Human   227 MEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKIT 291

  Fly   415 DFGFAKK-LRDRTW--TLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEMLVGYPPFYDEQPFG 476
            |||..|: ::|...  |.||||||:|||:::...:.:|||||.|||::|||:.|..|||::....
Human   292 DFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEK 356

  Fly   477 IYEKILSGKIEWERHMDPIAKDLIKKLLVNDRTKRLGNMKNGADDVKRHRWFKHLNWNDVYSKKL 541
            ::|.||..:|.:.|.:.|.||.|:..||..|..:|||.....|.::.:||:|..:.|..||.|||
Human   357 LFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKL 421

  Fly   542 KPPILPDVHHDGDTKNFDDY----------PEKDWKPAKAVDQRDLQYFNDF 583
            .||..|.|..:.||:.||:.          |::| ...:.||.....:|..|
Human   422 SPPFKPQVTSETDTRYFDEEFTAQMITITPPDQD-DSMECVDSERRPHFPQF 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	123/304 (40%)
AKT1	NP_005154.2	PH_PKB	4..111	CDD:269947	12/78 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..138		5/24 (21%)
		STKc_PKB_alpha	124..479	CDD:270746	134/350 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	450..480		6/24 (25%)