DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pka-C3 and Prkx

DIOPT Version :9

Sequence 1:	NP_730083.2	Gene:	Pka-C3 / 39733	FlyBaseID:	FBgn0000489	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_058675.1	Gene:	Prkx / 19108	MGIID:	1309999	Length:	355	Species:	Mus musculus

Alignment Length:	343	Identity:	198/343 - (57%)
Similarity:	265/343 - (77%)	Gaps:	5/343 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 DDEEDDDESEESSSV-----QTAKGVRKYHLDDYQIIKTVGTGTFGRVCLCRDRISEKYCAMKIL 305
            |.:.|..:::.|:..     :|:.....:.|.|:..|.||||||||||.|.:::...:|||:||:
Mouse    13 DPDHDPVKTKVSAPAADPKPRTSSQKAGHSLQDWDTIATVGTGTFGRVNLVKEKTGRQYCALKIM 77

  Fly   306 AMTEVIRLKQIEHVKNERNILREIRHPFVISLEWSTKDDSNLYMIFDYVCGGELFTYLRNAGKFT 370
            ::.:||||||.:||:||:.:|:||.|||:|.|.|:..|:..|||:.::|.||||||||||.|:|:
Mouse    78 SIPDVIRLKQEQHVQNEKAVLKEINHPFLIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFS 142

  Fly   371 SQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGFAKKLRDRTWTLCGTPEY 435
            |..|.|||.|||.|:|||||.:||||||||||:|::|:||:|:|||||||||.||||||||||||
Mouse   143 SVASVFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAKKLVDRTWTLCGTPEY 207

  Fly   436 IAPEIIQSKGHNKAVDWWALGVLIYEMLVGYPPFYDEQPFGIYEKILSGKIEWERHMDPIAKDLI 500
            :|||:||||||.:||||||||:||:|||.|:|||:|:.|||||:|||:.||::.|.:|..:||||
Mouse   208 LAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILACKIDFPRQLDFTSKDLI 272

  Fly   501 KKLLVNDRTKRLGNMKNGADDVKRHRWFKHLNWNDVYSKKLKPPILPDVHHDGDTKNFDDYPEKD 565
            |||||.|||:|||||||||:|:||||||:.:.|..|..:||||||:|.:..|||..||:.|||.:
Mouse   273 KKLLVVDRTRRLGNMKNGAEDIKRHRWFRGVEWESVPQRKLKPPIVPKLSGDGDISNFETYPESE 337

  Fly   566 WKPAKAVDQRDLQYFNDF 583
            .....:|..:||:.|.:|
Mouse   338 LDKTPSVSDKDLETFKNF 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	PTZ00263	262..583	CDD:140289	194/320 (61%)
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	186/290 (64%)
Prkx	NP_058675.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		4/28 (14%)
		PTZ00263	31..355	CDD:140289	194/323 (60%)
		STKc_PRKX_like	44..335	CDD:270763	186/290 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..355		15/38 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849453
Domainoid	1	1.000	374	1.000	Domainoid score	I867
eggNOG	1	0.900	-	-		E1_KOG0616
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55868
Inparanoid	1	1.050	429	1.000	Inparanoid score	I1723
Isobase	1	0.950	-	0	Normalized mean entropy	S582
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D277423at33208
OrthoFinder	1	1.000	-	-		FOG0000539
OrthoInspector	1	1.000	-	-		oto93586
orthoMCL	1	0.900	-	-		OOG6_100326
Panther	1	1.100	-	-	LDO	PTHR24353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4097
SonicParanoid	1	1.000	-	-		X4144
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740