Protein Alignment Pka-C3 and Pkn2

DIOPT Version :10

• Sequence 1: NP_730083.2
• Gene: Pka-C3 / 39733
• FlyBaseID: FBgn0000489
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_848769.2
• Gene: Pkn2 / 109333
• MGIID: 109211
• Length: 983
• Species: Mus musculus
• Alignment Length: 454
• Identity: 132/454 - (29%)
• Similarity: 235/454 - (51%)
• Gaps: 62/454 - (13%)

  Fly   179 QRPDPAT----NSR---SSSTATTTTTSSADHD------------NDVDEEDEEDD----ENEGE 220
            |.|.|||    ::|   .:..|:.:|.:..|.|            :.:.|.||..:    :..|:
Mouse   536 QTPVPATVPVVDARIPDLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGETDESSELRVLDIPGQ 600

  Fly   221 GNGRDADDATHDSSESIEEDDGNETDDEEDDDESEESSSVQTAKGVR-----------KYHLDDY 274
            |:         ::..:||.|..|.....:.:.|.....|.::..||.           ::.|.|:
Mouse   601 GS---------ETVFNIENDRNNLRPKSKSEYELSIPDSGRSCWGVGELDDKRAQQRFQFSLQDF 656

  Fly   275 QIIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNI---LREIRHPFVIS 336
            :....:|.|.||:|.|...:.:.:..|:|.|...:::...:::.:..|:.|   :..:||||:::
Mouse   657 RCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVN 721

  Fly   337 LEWSTKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPE 401
            |....:...::..:.:|..||:|..:: :...|:...:.||||.:|..|:|||..:|||||||.:
Mouse   722 LFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLD 785

  Fly   402 NLLINRDGHLKITDFGFAKK---LRDRTWTLCGTPEYIAPEIIQSKGHNKAVDWWALGVLIYEML 463
            |||::.:|.:||.|||..|:   ..|||.|.|||||::|||::....:.:|||||.|||||||||
Mouse   786 NLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEML 850

  Fly   464 VGYPPFYDEQPFGIYEKILSGKIEWERHMDPIAKDLIKKLLVNDRTKRLGNMKNGADDVKRHRWF 528
            ||..||..:....:::.|::.::.:.|.:...|..::::||..:..:|||..:..|:|||:|.:|
Mouse   851 VGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFF 915

  Fly   529 KHLNWNDVYSKKLKPPILPDVHHDGDTKNFDD---------YPEKDWKPAKAVDQRDLQYFNDF 583
            :..:|:.:..||:|||.:|.:....|..||||         .|.::   .:.:.:.:.:.|:||
Mouse   916 RLTDWSALMDKKVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPRE---PRILLEEEQEMFHDF 976

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	104/305 (34%)
Pkn2	NP_848769.2	HR1_PKN_1	42..107	CDD:212012
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	107..135
		HR1_PKN2_2	128..201	CDD:212021
		HR1_PKN2_3	209..282	CDD:212025
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	351..382
		Necessary to rescue apical junction formation	381..462
		C2_PKN-like	389..472	CDD:176069
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	553..588		5/34 (15%)
		STKc_PKN	656..981	CDD:270741	107/325 (33%)
		Necessary for the catalytic activity. /evidence=ECO:0000250	916..976		14/62 (23%)
		Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA. /evidence=ECO:0000250	977..983		132/454 (29%)