DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sff and BRSK2

DIOPT Version :9

Sequence 1:	NP_648814.3	Gene:	sff / 39732	FlyBaseID:	FBgn0036544	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_016874022.1	Gene:	BRSK2 / 9024	HGNCID:	11405	Length:	880	Species:	Homo sapiens

Alignment Length:	902	Identity:	450/902 - (49%)
Similarity:	561/902 - (62%)	Gaps:	113/902 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AENCQFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLID 73
            |::.|:|||||||||||||||||||||||||..:||||||:|||||||||||||||||||:|||:
Human    10 AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIE 74

  Fly    74 HPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICH 138
            |||||.|.|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||
Human    75 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICH 139

  Fly   139 RDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGV 203
            ||||||||||||||||:||||||||||...|:|||||||||||||||||||||||||||||||||
Human   140 RDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGV 204

  Fly   204 ILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPW 268
            ||:|||||||||||||||||||||||||||:|||:||||||||||||||:..|||||..|.:|.|
Human   205 ILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIW 269

  Fly   269 VTAGGKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVI 333
            . .|||.|.|.|.|:...||...:|:...:|||||:::.|||||:::.||:|:|||...|.||:|
Human   270 Y-IGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMI 333

  Fly   334 YFLLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRIN--GTNAPSYGQI------SEG 390
            |||||:||.|.|:.||:|   ...|:|   :||||||:|:..:|  |...|....:      ..|
Human   334 YFLLLDRKERYPSQEDED---LPPRNE---IDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGG 392

  Fly   391 SPLTPRR----------QAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQA 445
            ||:..||          :|...:|......|.:.|....:.|:..:|....|   ||:||.:...
Human   393 SPVPARRAIEMAQHGQSKAMFSKSLDIAEAHPQFSKEDRSRSISGASSGLST---SPLSSPRPIR 454

  Fly   446 NAISRPSSP---------AAGTRHSTYGDRDRSGH----HSSVSRTP--------SHSSQKSIEG 489
            ..:..|..|         |..|.....|...|.||    .:::...|        :..:.|.::|
Human   455 KLVLPPPPPEPPFVARPLATSTEPEACGSASRPGHVLPLQAALRPDPKTQTLPCKAKLTDKPLQG 519

  Fly   490 D-------VVVVREPRIERRDSLRQERGGGSPRDRGDCGIPPGSPGGNSSGSTSASPSVHHRANS 547
            .       ....|.|.......|....|..:.|      :||..|......:|          .|
Human   520 TKSNPFPASTPARPPATGLCPQLAPPLGPPALR------VPPRPPPAGIEPNT----------KS 568

  Fly   548 GPTIAISMFHDPDSNSVVNPNGSPMMN-NSSPGMPGSPCNTP------GGQLWKTRLTNIKNSFL 605
            .|||.::....|..:.:..|.|:|:.. ..||.  |:|..||      ||..|:.||.:||||||
Human   569 VPTIQVTPHPSPRGSPLPTPKGTPVHTPKESPA--GTPNPTPPSSPSVGGVPWRARLNSIKNSFL 631

  Fly   606 GSPRFHRRKMQVSADE--VHLTPESSPELTKRSWFGNLITTEKDETFTILVKGKPIATVKAHLIH 668
            |||||||||:||...|  .:|||||||||.|:|||||.|:.||:|...:::|.||::::||.::|
Human   632 GSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKDKPLSSIKADIVH 696

  Fly   669 AFLSMAELSHSVVSPTSFRVEYKRNGNGPVMFQRHVKFQVDISAICKQGDIADM---LFALTFTL 730
            ||||:..|||||:|.||||.|||..| ||.:||:.|||||||:  ..:|..|..   ::::||||
Human   697 AFLSIPSLSHSVISQTSFRAEYKATG-GPAVFQKPVKFQVDIT--YTEGGEAQKENGIYSVTFTL 758

  Fly   731 LSGNIRRFRRICEHIQSQVCSKRFPGPSSPPTVTSVTQAVSESSSCGSVSSERLSYKRQVIEN-- 793
            |||..|||:|:.|.||:|:.|..     .||    ..|.:|::::|..:.:.|||.....:.|
Human   759 LSGPSRRFKRVVETIQAQLLSTH-----DPP----AAQHLSDTTNCMEMMTGRLSKCGSPLSNFF 814

  Fly   794 DMENDSIFSYKSGNGRRASTT-----------NNNNANPVDIPGSPIAVRSNSETAE 839
            |:........|:|...:|.:|           ::..|.|.  ||......:..:||:
Human   815 DVIKQLFSDEKNGQAAQAPSTPAKRSAHGPLGDSAAAGPG--PGGDAEYPTGKDTAK 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	227/252 (90%)
		S_TKc	18..269	CDD:214567	225/250 (90%)
		UBA_BRSK	298..350	CDD:270525	30/51 (59%)
BRSK2	XP_016874022.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155262
Domainoid	1	1.000	469	1.000	Domainoid score	I459
eggNOG	1	0.900	-	-		E1_KOG0588
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123829
Inparanoid	1	1.050	728	1.000	Inparanoid score	I617
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45378
OrthoDB	1	1.010	-	-		D302185at33208
OrthoFinder	1	1.000	-	-		FOG0002008
OrthoInspector	1	1.000	-	-		otm40715
orthoMCL	1	0.900	-	-		OOG6_100252
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1318
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770