DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sff and HSL1

DIOPT Version :9

Sequence 1:	NP_648814.3	Gene:	sff / 39732	FlyBaseID:	FBgn0036544	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_012821.2	Gene:	HSL1 / 853760	SGDID:	S000001584	Length:	1518	Species:	Saccharomyces cerevisiae

Alignment Length:	1086	Identity:	272/1086 - (25%)
Similarity:	432/1086 - (39%)	Gaps:	317/1086 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKL------------------------S 55
            |||::|.||||||.:|.|:|..:...|:..||||:.::|.                        |
Yeast    78 VGPWKLGKTLGKGSSGRVRLAKNMETGQLAAIKIVPKKKAFVHCSNNGTVPNSYSSSMVTSNVSS 142

  Fly    56 ESVLMK------------VEREIAIMKLIDHPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVK 108
            .|:..:            :||||.|||||.|.:|:.|.:|:|||..|||:||:|.|||||||||.
Yeast   143 PSIASREHSNHSQTNPYGIEREIVIMKLISHTNVMALFEVWENKSELYLVLEYVDGGELFDYLVS 207

  Fly   109 KGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKN-NIKIADFGMASLQPAGSMLE 172
            ||:|..:||..:|:||:..:.:|||.:||||||||||||||:|| .|||||||||:|:....:|:
Yeast   208 KGKLPEREAIHYFKQIVEGVSYCHSFNICHRDLKPENLLLDKKNRRIKIADFGMAALELPNKLLK 272

  Fly   173 TSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHF 237
            |||||||||.||::.|..|.|..:||||||::|:|||.|.|||:|||:::||.||:.|.:.:|..
Yeast   273 TSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPFNDDNIKKLLLKVQSGKYQMPSN 337

  Fly   238 VPPDCQSLLRGMIEVNPDRRLTLAEINRHPWV-------------------TAGGKGELELEL-- 281
            :..:.:.|:..::.::|::|:|..||.:||.:                   .|.||...:|.|
Yeast   338 LSSEARDLISKILVIDPEKRITTQEILKHPLIKKYDDLPVNKVLRKMRKDNMARGKSNSDLHLLN 402

  Fly   282 ---PMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVIYFLLLERKRR 343
               |  .:|..|   :...:|..:|.::..|.....:|.:..:||....:.||:.|.|||:.|:|
Yeast   403 NVSP--SIVTLH---SKGEIDESILRSLQILWHGVSRELITAKLLQKPMSEEKLFYSLLLQYKQR 462

  Fly   344 RPALEDDDEIAQKSRSELDAVDPPR--------------------KRL--------DTCRINGTN 380
            ...........:||.:| .:|:.||                    |.|        ||..:|..|
Yeast   463 HSISLSSSSENKKSATE-SSVNEPRIEYASKTANNTGLRSENNDVKTLHSLEIHSEDTSTVNQNN 526

  Fly   381 APSYGQISEGSPLTPRRQAFNFRSYSSTRNHQ-----------------------RRSPTTVTSS 422
            |.:.......:|:..::..|:..:.|...:.:                       |.|.|:::|.
Yeast   527 AITGVNTEINAPVLAQKSQFSINTLSQPESDKAEAEAVTLPPAIPIFNASSSRIFRNSYTSISSR 591

  Fly   423 VRSSSYHSPTRCNSPMSSAQQQA--NAISRPSSPAAGTRHSTYGDRDRSGHHSSVSRTPSHS--S 483
            .|.|...|.:|.:...|::::..  |.:..|..|.:.:|:|.    .|...|:|.|....|.  |
Yeast   592 SRRSLRLSNSRLSLSASTSRETVHDNEMPLPQLPKSPSRYSL----SRRAIHASPSTKSIHKSLS 652

  Fly   484 QKSIEGDVVVVR-----------------------------------------------EPRIER 501
            :|:|...|...|                                               ||....
Yeast   653 RKNIAATVAARRTLQNSASKRSLYSLQSISKRSLNLNDLLVFDDPLPSKKPASENVNKSEPHSLE 717

  Fly   502 RDS------------------LRQERGGGSPRD-----RGDCGIPPGSPGGNSSGSTSASPSVH- 542
            .||                  |.:|......||     :.|.         .||..|.....|.
Yeast   718 SDSDFEILCDQILFGNALDRILEEEEDNEKERDTQRQRQNDT---------KSSADTFTISGVST 773

  Fly   543 HRANSGPTIAISMFHDPDSNSVVNPNGSPMMNNSSPGMPGSPC----NTPGGQLW------KTRL 597
            ::.|.||.....:     ..:..|.:..|..|.|  |:...|.    ||......      :..|
Yeast   774 NKENEGPEYPTKI-----EKNQFNMSYKPSENMS--GLSSFPIFEKENTLSSSYLEEQKPKRAAL 831

  Fly   598 TNIKNSFLG---------SPRFHRRKMQVSADEVH-LTPESSPELTKRSWFGNLITTEKDETFTI 652
            ::|.|||..         ..:..|.::|...|... |.|....||...|       ...|:
Yeast   832 SDITNSFNKMNKQEGMRIEKKIQREQLQKKNDRPSPLKPIQHQELRVNS-------LPNDQ---- 885

  Fly   653 LVKGKPIATVKAHLIHAFLSMAELSHSVVSPTSFRVEYKRNG--------------NGPVMFQRH 703
               |||..::            :...::..|.:.:||....|              .|.:....|
Yeast   886 ---GKPSLSL------------DPRRNISQPVNSKVESLLQGLKFKKEPASHWTHERGSLFMSEH 935

  Fly   704 VKFQV------------------------DISAICKQGDIADMLFALTFTLLSGNIRRFRRICEH 744
            |:.:.                        |.|.:.:...|...:.:|..:.|:.:: .|:.:.:.
Yeast   936 VEDEKPVKASDVSIESSYVPLTTVATSSRDPSVLAESSTIQKPMLSLPSSFLNTSM-TFKNLSQI 999

  Fly   745 IQSQVCSKRFPGPSSPPTVTSVTQAVSESSSCGSVS-----SERLSYKR------QVIENDME-- 796
            :......|....|.:.....:::..:.:.|:..|::     :..||.||      ..:.||::
Yeast  1000 LADDGDDKHLSVPQNQSRSVAMSHPLRKQSAKISLTPRSNLNANLSVKRNQGSPGSYLSNDLDGI 1064

  Fly   797 NDSIFSYKSGNG---RRASTTNNNNANPVDIPGSPIAVRSNSETAE 839
            :|..|:.:....   .:|....||:.:...|..||   :::|.|.|
Yeast  1065 SDMTFAMEIPTNTFTAQAIQLMNNDTDNNKINTSP---KASSFTKE 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	134/289 (46%)
		S_TKc	18..269	CDD:214567	132/287 (46%)
		UBA_BRSK	298..350	CDD:270525	14/51 (27%)
HSL1	NP_012821.2	STKc_BRSK1_2	79..369	CDD:270983	134/289 (46%)
HSL1	NP_012821.2	AMPKA_C_like	1347..1517	CDD:418410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0588
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1348
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46635
orthoMCL	1	0.900	-	-		OOG6_100252
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R187
SonicParanoid	1	1.000	-	-		X1318
TreeFam	0	0.000	Not matched by this tool.
	8	7.790