Protein Alignment sff and KIN1

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_010407.1
• Gene: KIN1 / 851700
• SGDID: S000002529
• Length: 1064
• Species: Saccharomyces cerevisiae
• Alignment Length: 1012
• Identity: 236/1012 - (23%)
• Similarity: 388/1012 - (38%)
• Gaps: 290/1012 - (28%)

  Fly    15 VGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINR--------------EKLSESVL---MKV 62
            :|.:...:|:|.|..|.|||..|....:..|:||:||              .|..:.||   .|:
Yeast   117 LGDWEFVETVGAGSMGKVKLAKHRYTNEVCAVKIVNRATKAFLHKEQMLPPPKNEQDVLERQKKL 181

  Fly    63 EREI----------AIMKLIDHPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEA 117
            |:||          ::.:::.|||:..|.::.....:.|::.|:||||:|.||:::.|.:...:|
Yeast   182 EKEISRDKRTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREHQA 246

  Fly   118 RKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYAC 182
            |||.|.|.|||.:.|:::|.|||||.||:::.:.:.|||.|||::::..:...|.|.|||.::|.
Yeast   247 RKFARGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQLHTFCGSLYFAA 311

  Fly   183 PEVIRGEKYDGRKADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLR 247
            ||:::...|.|.:.||||.||:|:.|:.|.:||||:|...|.||:|:|....|..:..:..|||.
Yeast   312 PELLKANPYTGPEVDVWSFGVVLFVLVCGKVPFDDENSSVLHEKIKQGKVEYPQHLSIEVISLLS 376

  Fly   248 GMIEVNPDRRLTLAEINRHPWVTAGGKGELELELPMMEVVQTHVIP-TATAVDPDVLNAICSLGC 311
            .|:.|:|.||.||.::..|.|:..|..|.....||..       :| |...:|.:||..:..|..
Yeast   377 KMLVVDPKRRATLKQVVEHHWMVRGFNGPPPSYLPKR-------VPLTIEMLDINVLKEMYRLEF 434

  Fly   312 FKEKEKLIQELLS------------------------SSHN------TEKV------------IY 334
            ..:.|:....|:|                        ||.|      ||..            ||
Yeast   435 IDDVEETRSVLVSIITDPTYVLLSRQYWTLAAKMNAESSDNGNAPNITESFEDPTRAYHPMISIY 499

  Fly   335 FL---LLERK-------RRRPALEDDDEI-----------------AQKSRSEL----------- 361
            :|   :|:||       ::|.:.|:.:::                 |.||..|.
Yeast   500 YLTSEMLDRKHAKIRNQQQRQSHENIEKLSEIPESVKQRDVEVNTTAMKSEPEATLATKDTSVPF 564

  Fly   362 -----DAVDPPRKRLDTCRI----NGTNAPSYGQISEG---------SPLTPRRQAF-NFRSYSS 407
                 |..:||...|...|:    ....:|:..:.|:.         || ||:...: .||..|:
Yeast   565 TPKNSDGTEPPLHVLIPPRLAMPEQAHTSPTSRKSSDNQRREMEYALSP-TPQGNDYQQFRVPST 628

  Fly   408 T--------------RNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQA-----NAISRPSS 453
            |              :..|||..|...:||.|::     ..|.|:.....:|     ...::||.
Yeast   629 TGDPSEKAKFGNIFRKLSQRRKKTIEQTSVNSNN-----SINKPVQKTHSRAVSDFVPGFAKPSY 688

  Fly   454 PAAGTRHSTYGDRD-RSGHHSSVSRTPSHSS-------QKSIEGDVVVVREPRIER--------R 502
            .:..|.:......| |.|:.......|:.:.       :|.||.|::.:.:...:.        |
Yeast   689 DSNYTMNEPVKTNDSRGGNKGDFPALPADAENMVEKQREKQIEEDIMKLHDINKQNNEVAKGSGR 753

  Fly   503 DSLRQERGGGSPRDRGDCGIPP--GSPGGNSSGSTSASPSVHHRANSGPTIAISMFHDPDSNSVV 565
            ::...::..||..|... .:||  .:.|.....|..|....|.|..|
Yeast   754 EAYAAQKFEGSDDDENH-PLPPLNVAKGRKLHPSARAKSVGHARRES------------------ 799

  Fly   566 NPNGSPMMNNSSPGMPGSPCNTPGGQLWKT------------RLTNIKNSFLGSPRFHRRKMQVS 618
                   :....|.||.|.  .|..:|..|            .|.|:.:....|...|.....::
Yeast   800 -------LKYMRPPMPSSA--YPQQELIDTGFLESSDDNKSDSLGNVTSQTNDSVSVHSVNAHIN 855

  Fly   619 ADEV--HLTPESSPELTKRSWFGNLITTEKDETFTILVKG---------KPIATVKAHLIHAFLS 672
            :..|  .||.|...:...|:..|::.:.  |...::.:||         ||:..|:..::.....
Yeast   856 SPSVEKELTDEEILQEASRAPAGSMPSI--DFPRSLFLKGFFSVQTTSSKPLPIVRYKIMFVLRK 918

  Fly   673 MAELSHSVVSPTSFRVEYKRNGNGPVMFQRHVKFQVDISAICKQGDIADMLFALTFTLLSGNIRR 737
            |             .:|:|....|.|..||   |..:..|..::|....::      .||.:
Yeast   919 M-------------NIEFKEVKGGFVCMQR---FSSNNVAAKREGTPRSIM------PLSHH--- 958

  Fly   738 FRRICEHIQSQVCSKRFPGPSSPPTV-------TSVTQAVSESSSCGSVSSERLSYKRQVIENDM 795
                 |.|:.|..:|.  .||||.|.       ||:|:...:....|:               .:
Yeast   959 -----ESIRRQGSNKY--SPSSPLTTNSIHQRKTSITETYGDDKHSGT---------------SL 1001

  Fly   796 ENDSIFSYKSGNGRRASTTNNNNANPVDIPGSPIAVR 832
            ||    .::.|:|....||...  .|:......:.||
Yeast  1002 EN----IHQQGDGSEGMTTTEK--EPIKFEIHIVKVR 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	100/279 (36%)
		UBA_BRSK	298..350	CDD:270525	20/103 (19%)
KIN1	NP_010407.1	STKc_Kin1_2	118..398	CDD:270979	100/279 (36%)
		MARK_C_like	890..1062	CDD:213377	39/196 (20%)