DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sff and BRSK1

DIOPT Version :9

Sequence 1:	NP_648814.3	Gene:	sff / 39732	FlyBaseID:	FBgn0036544	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_115806.1	Gene:	BRSK1 / 84446	HGNCID:	18994	Length:	778	Species:	Homo sapiens

Alignment Length:	799	Identity:	425/799 - (53%)
Similarity:	528/799 - (66%)	Gaps:	127/799 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ENCQFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDH 74
            ::.|:||||||||||||||||||||||||:.|:||||||:|||||||||||||||||||:|||:|
Human    26 QHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEH 90

  Fly    75 PHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHR 139
            ||||.|.|||||||||||:|||||||||||||||||||||||||||||||:||||||||:|||||
Human    91 PHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHR 155

  Fly   140 DLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVI 204
            |||||||||||||||:||||||||||...|:||||||||||||||||:|||||||:||:||||||
Human   156 DLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVI 220

  Fly   205 LYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWV 269
            |:|||||||||||||||||||||||||||:|||:||||||||||||||.|::||:|.:|.:|||.
Human   221 LFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWY 285

  Fly   270 TAGGKGELELELPMMEV-----VQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNT 329
             .|||.|.:   |.:|.     |....:|:...:|||||.::.|||||:::|:|.:||.|...|.
Human   286 -LGGKHEPD---PCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQ 346

  Fly   330 EKVIYFLLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRI--NGTNAPSYGQI----- 387
            ||:||:|||:||.|.|:.||.|   ...|::   |||||||:|:..:  :|...|....:
Human   347 EKMIYYLLLDRKERYPSCEDQD---LPPRND---VDPPRKRVDSPMLSRHGKRRPERKSMEVLSI 405

  Fly   388 ----SEGSPLTPRRQAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQANAI 448
                ..|||: |.|:|.....:|    .:.||.:..::.:.||...||   .||:.|
Human   406 TDAGGGGSPV-PTRRALEMAQHS----QRSRSVSGASTGLSSSPLSSP---RSPVFS-------- 454

  Fly   449 SRPSSPAAGTRHSTYGDRDRSGHHSSVSRTPSHSSQKSIEGDVVVVREPRIERRDSLRQERGGG- 512
               .||..|.     ||..|.| .|..|:|.:..|                      |..||||
Human   455 ---FSPEPGA-----GDEARGG-GSPTSKTQTLPS----------------------RGPRGGGA 488

  Fly   513 -------SPRDRGDCGIPPGSPGGNSSGSTSASPSVHHRANSGPTIAISMFHDPDSNSVVNPNGS 570
                   |.|.....| |||||  .|||.|.                   .|.|......:|.|:
Human   489 GEQPPPPSARSTPLPG-PPGSP--RSSGGTP-------------------LHSPLHTPRASPTGT 531

  Fly   571 PMMNNSSPGMPGSPCNTPGGQLWKTRLTNIKNSFLGSPRFHRRKMQV-SADEV-HLTPESSPELT 633
            |   .::|  |.||....||..|::||.:|:|||||||||||||||| :|:|: .|||||||||.
Human   532 P---GTTP--PPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELA 591

  Fly   634 KRSWFGNLITTEKDETFTILVKGKPIATVKAHLIHAFLSMAELSHSVVSPTSFRVEYKRNGNGPV 698
            |||||||.|:.:|:|...:::|.||::::||.::|||||:..|||||:|.||||.|||.:| ||.
Human   592 KRSWFGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASG-GPS 655

  Fly   699 MFQRHVKFQVDISAI-------CKQGDIADMLFALTFTLLSGNIRRFRRICEHIQSQVCSKRFPG 756
            :||:.|:||||||:.       .:.|.....::::||||:||..|||:|:.|.||:|:.|..
Human   656 VFQKPVRFQVDISSSEGPEPSPRRDGSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTH--- 717

  Fly   757 PSSPPTVTSVTQAVSESSS 775
              ..|:|    ||:::..:
Human   718 --DQPSV----QALADEKN 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	222/252 (88%)
		S_TKc	18..269	CDD:214567	220/250 (88%)
		UBA_BRSK	298..350	CDD:270525	28/51 (55%)
BRSK1	NP_115806.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		0/2 (0%)
		STKc_BRSK1_2	32..285	CDD:270983	222/252 (88%)
		UBA_BRSK	314..367	CDD:270525	28/52 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..548		70/265 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	719..778		4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	469	1.000	Domainoid score	I459
eggNOG	1	0.900	-	-		E1_KOG0588
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	728	1.000	Inparanoid score	I617
Isobase	1	0.950	-	0	Normalized mean entropy	S1348
OMA	1	1.010	-	-		QHG45378
OrthoDB	1	1.010	-	-		D302185at33208
OrthoFinder	1	1.000	-	-		FOG0002008
OrthoInspector	1	1.000	-	-		otm40715
orthoMCL	1	0.900	-	-		OOG6_100252
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R187
SonicParanoid	1	1.000	-	-		X1318
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820