DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sff and Brsk2

DIOPT Version :9

Sequence 1:	NP_648814.3	Gene:	sff / 39732	FlyBaseID:	FBgn0036544	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_001009930.1	Gene:	Brsk2 / 75770	MGIID:	1923020	Length:	719	Species:	Mus musculus

Alignment Length:	785	Identity:	424/785 - (54%)
Similarity:	509/785 - (64%)	Gaps:	142/785 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AENCQFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLID 73
            |::.|:|||||||||||||||||||||:|||..:||||||:|||||||||||||||||||:|||:
Mouse    11 AQHAQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIE 75

  Fly    74 HPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICH 138
            |||||.|.|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||
Mouse    76 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICH 140

  Fly   139 RDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGV 203
            ||||||||||||:|||:||||||||||...|:|||||||||||||||||||||||||||||||||
Mouse   141 RDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGV 205

  Fly   204 ILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPW 268
            ||:|||||||||||||||||||||||||||:|||:||||||||||||||:..|||||..|.:|.|
Mouse   206 ILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIW 270

  Fly   269 VTAGGKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVI 333
            . .|||.|.|.|.|:...||...:|:...:|||||:::.|||||:::.||:|:|||...|.||:|
Mouse   271 Y-IGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMI 334

  Fly   334 YFLLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRINGTNAPSYGQISEGSPLTPRRQ 398
            |||||:||.|.|:.||:|   ...|:|   :||||||:|                  ||:..|
Mouse   335 YFLLLDRKERYPSHEDED---LPPRNE---IDPPRKRVD------------------SPMLNR-- 373

  Fly   399 AFNFRSYSSTRNHQRRSPTTVTSSVRS-SSYHSPTRCNSPMSSAQQQANAISRPSSPAAGTRHST 462
                        |.:|.|...:..|.| :...||......:..||
Mouse   374 ------------HGKRRPERKSMEVLSVTDGGSPVPARRAIEMAQ-------------------- 406

  Fly   463 YGDRDR--SGHHSSVSRTPSHSSQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRGDCGIPPG 525
            :|.|.|  ||..|.:|.:|..|              ||:....|.|     |||     ...|.|
Mouse   407 HGQRSRSISGASSGLSTSPLSS--------------PRVTPHPSPR-----GSP-----LPTPKG 447

  Fly   526 SPGGNSSGSTSASPSVHHRANSGPTIAISMFHDPDSNSVVNPNGSPMMNNSSPGMPGSPCNTPGG 590
            :|                            .|.|..:....||.:|         |.||  :.||
Mouse   448 TP----------------------------VHTPKESPAGTPNPTP---------PSSP--SVGG 473

  Fly   591 QLWKTRLTNIKNSFLGSPRFHRRKMQVSADE--VHLTPESSPELTKRSWFGNLITTEKDETFTIL 653
            ..|:|||.:|||||||||||||||:||...|  .:|||||||||.|:|||||.|..||:|...::
Mouse   474 VPWRTRLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFINLEKEEQIFVV 538

  Fly   654 VKGKPIATVKAHLIHAFLSMAELSHSVVSPTSFRVEYKRNGNGPVMFQRHVKFQVDISAICKQGD 718
            :|.||::::||.::|||||:..|||||:|.||||.|||..| ||.:||:.|||||||:  ..:|.
Mouse   539 IKDKPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATG-GPAVFQKPVKFQVDIT--YTEGG 600

  Fly   719 IADM---LFALTFTLLSGNIRRFRRICEHIQSQVCSKRFPGPSSPPTVTSVTQAVSESSSCGSVS 780
            .|..   ::::|||||||..|||:|:.|.||:|:.|.. ..||:        |.:|::::|..|.
Mouse   601 EAQKENGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTH-DQPSA--------QHLSDTTNCMEVM 656

  Fly   781 SERLS 785
            :.|||
Mouse   657 TGRLS 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	225/252 (89%)
		S_TKc	18..269	CDD:214567	223/250 (89%)
		UBA_BRSK	298..350	CDD:270525	30/51 (59%)
Brsk2	NP_001009930.1	STKc_BRSK1_2	18..271	CDD:270983	225/252 (89%)
Brsk2	NP_001009930.1	UBA_BRSK	298..351	CDD:270525	30/52 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845734
Domainoid	1	1.000	469	1.000	Domainoid score	I455
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123829
Inparanoid	1	1.050	729	1.000	Inparanoid score	I614
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45378
OrthoDB	1	1.010	-	-		D302185at33208
OrthoFinder	1	1.000	-	-		FOG0002008
OrthoInspector	1	1.000	-	-		otm42789
orthoMCL	1	0.900	-	-		OOG6_100252
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1318
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910