DRSC/TRiP Functional Genomics Resources

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Protein Alignment sff and Nuak2

DIOPT Version :10

Sequence 1:NP_648814.3 Gene:sff / 39732 FlyBaseID:FBgn0036544 Length:861 Species:Drosophila melanogaster
Sequence 2:NP_001181954.1 Gene:Nuak2 / 74137 MGIID:1921387 Length:639 Species:Mus musculus


Alignment Length:559 Identity:173/559 - (30%)
Similarity:257/559 - (45%) Gaps:141/559 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 YRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKL-SESVLMKVEREIAIMKLIDHPHVLGLS 81
            |...:|||||..|.||..... .|:.||||.|.::|: .|..|:.:.|||.||..::|||::.:.
Mouse    57 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPHIIAIH 120

  Fly    82 D--------VYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICH 138
            :        |:||...:.:::|:.|.|:|:||:.::.||:.::||.|||||:|||.:||.:.|.|
Mouse   121 EVGRSRLVTVFENSSKIVIVMEYASRGDLYDYISERPRLSERDARHFFRQIVSALHYCHQNGIVH 185

  Fly   139 RDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGV 203
            ||||.||:|||...||||||||:::|...|..|:|.||||.||.||::.|:.|.|.:.|.||.||
Mouse   186 RDLKLENILLDANGNIKIADFGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDSWSLGV 250

  Fly   204 ILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPW 268
            :||.|:.|.:|||..:.:.|::::..|.:..|. .|.|...|:|.::.|||.||.||.::..|.|
Mouse   251 LLYILVHGTMPFDGQDHKTLVKQISNGAYREPP-KPSDACGLIRWLLMVNPTRRATLEDVASHWW 314

  Fly   269 VTAG---GKGELELELPMMEVVQTHVIPT-----ATAVD-------PDVLNA--ICSLGCFKEKE 316
            |..|   |.||       .|.::....|:     |:..|       |.:.|.  :||.  ||:. 
Mouse   315 VNWGYTTGVGE-------QEALREGGHPSGDFGRASMADWLRRSSRPLLENGAKVCSF--FKQH- 369

  Fly   317 KLIQELLSSSHNTEKVIYFLLLERKRRRPALEDDDEIAQKSRSELDAV-----DP-------PRK 369
                  :....:|.              |.||....: :|||.|.|..     ||       |.|
Mouse   370 ------VPGGGSTV--------------PGLERQHSL-KKSRKENDMAQNLQGDPAEDTSSRPGK 413

  Fly   370 ---RLDTCRINGTNAPSYGQISE------------GSP-----LTPRRQAFNFRSYSSTRNHQRR 414
               :|....:...::.|.|::.|            |.|     |.||:....       ::.|| 
Mouse   414 SSLKLPKGILKKKSSTSSGEVQEDPQELRPVPDTPGQPVPAVSLLPRKGILK-------KSRQR- 470

  Fly   415 SPTTVTSSVRSSSYHSPTRCNS--------------PMSSAQQQANAI--------------SRP 451
                     .|..|.||....|              |:.....||:.:              || 
Mouse   471 ---------ESGYYSSPEPSESGELLDASDVFVSGDPVEQKSPQASGLLLHRKGILKLNGKFSR- 525

  Fly   452 SSPAAGTRHSTYGDRDR--SGHHSSVSRTPSHS-SQKSI 487
             :...||..||:|..|:  |.|.::....||.: |:.||
Mouse   526 -TALEGTTPSTFGSLDQLASSHPAARPSRPSGAVSEDSI 563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sffNP_648814.3 STKc_BRSK1_2 16..269 CDD:270983 110/259 (42%)
UBA_BRSK 298..350 CDD:270525 11/60 (18%)
Nuak2NP_001181954.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Protein Kinases, catalytic domain 53..315 CDD:473864 110/259 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 372..485 29/144 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 529..575 13/35 (37%)
Blue background indicates that the domain is not in the aligned region.

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