Protein Alignment sff and Sik3

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_001258145.2
• Gene: Sik3 / 684112
• RGDID: 1593938
• Length: 1369
• Species: Rattus norvegicus
• Alignment Length: 820
• Identity: 228/820 - (27%)
• Similarity: 359/820 - (43%)
• Gaps: 182/820 - (22%)

  Fly    15 VGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHVLG 79
            :|.|.:::|:|||...:||...|.|...|||||||::.:|.|..|.|:.||:.|||::.|||::.
  Rat    63 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIR 127

  Fly    80 LSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPE 144
            |..|.|.::.:||:.|:.||||:||:||..||:..||||:.|:||::|:.|||..:|.|||||.|
  Rat   128 LYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAE 192

  Fly   145 NLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALL 209
            |||||...||||||||.::|...|.:|:|.||||.||.||:..|::|||.|.|:||.||:||.|:
  Rat   193 NLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV 257

  Fly   210 VGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTAGGK 274
            .||||||...|:.|..:|..|.|.||.|:..:|:.|:|.|:.::|::||::.:|.||.|:.. |.
  Rat   258 CGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICRHRWMKL-GD 321

  Fly   275 GELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVIYFLLLE 339
            .:...|..:.|..|......|..::.:||.|:..:|.  :||:.:|.|.|.:::....||.||.:
  Rat   322 ADPNFERLIAECQQLKEERQAEPLNDEVLLAMEDMGL--DKERTLQSLRSDAYDHYSAIYSLLCD 384

  Fly   340 RKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRINGTNAPSYGQISEGSPLTPRRQAFNFRS 404
            |.::                                 |.|..|.      ..|.||  ||..|::
  Rat   385 RHKK---------------------------------NKTLRPG------ALPSTP--QAMTFQA 408

  Fly   405 YSSTRNHQRRSPTTVTSSVRSSSYHSP-TRCNSPMSSAQQQANAISRPSSPAAGTRHSTYGDRDR 468
            ..:.:..|  :.|.:..||......:| .:...|..:....::....| ||.|..|:
  Rat   409 PVNIQAEQ--TGTAMNISVPQVQLINPENQIIEPDGAVNLDSDEGEEP-SPEALVRY-------- 462

  Fly   469 SGHHSSVSRTPSHSSQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRGDCGIPPGSPGGN-SS 532
                            .|:....|.|.:||.|..|.:::              :.||.||.| .:
  Rat   463 ----------------LSMRRHTVGVADPRTEVMDEMQK--------------LLPGFPGANPQT 497

  Fly   533 GSTSASPSVHHRANSGPTIAI----------SMFHDPDSNSVVNPNGSPMMNNSSPG-------- 579
            .....:|:::...|..|..::          .....|.:..::|..| |:...:|.|
  Rat   498 PFLQVAPNMNFMHNLLPMQSLQPTGQLEYKEQSLLQPPTLQLLNGMG-PLGRRASDGGANIQLHA 561

  Fly   580 ----------------MPGSPCNTPGGQLWKTRLTNIKNSFLGSP-----------RFHRRKMQV 617
                            .|..|..||..:          .|..|.|           |..|..:.:
  Rat   562 QQLLKRPRGPSPLVTMTPAVPAVTPVDE----------ESSDGEPDQEAVQRYLANRSKRHTLAM 616

  Fly   618 SADEVHLTPESSPELTKRS-----WFGNLITTEKDETFTILVKGKPIATVKAHL-IHAFLSMAEL 676
            ::....:.|:...:|.::|     |..:|:..:...|:      |...|:  || ...|..:...
  Rat   617 TSPTAEIPPDLQRQLGQQSFRSRVWPPHLVPDQHRSTY------KDSNTL--HLPTERFSPVRRF 673

  Fly   677 SHSVVSPTSFRVEYKRNGNGPVMFQRHVKFQVDISAICKQ------GDIADMLFALTFT--LLSG 733
            |....|..:|:...:|.||...:.|        :...|:|      |.:.:.....|..  :|..
  Rat   674 SDGAASIQAFKAHLERMGNSSSIKQ--------LQQECEQLQKMYGGQVDERTLEKTQQQHMLYQ 730

  Fly   734 NIRRFRRICEHIQSQVCSKRFPGPSSPPTVTSVTQAVSES 773
            ..:..:.:.:.||..:|    |...|||     .||..|:
  Rat   731 QEQHHQILQQQIQDSIC----PPQPSPP-----LQAACEN 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	125/252 (50%)
		UBA_BRSK	298..350	CDD:270525	14/51 (27%)
Sik3	NP_001258145.2	STKc_SIK	65..317	CDD:270973	124/251 (49%)
		UBA_like_SF	346..390	CDD:473871	14/78 (18%)