Protein Alignment sff and Mark4

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_001178000.1
• Gene: Mark4 / 680407
• RGDID: 1591792
• Length: 752
• Species: Rattus norvegicus
• Alignment Length: 827
• Identity: 256/827 - (30%)
• Similarity: 380/827 - (45%)
• Gaps: 202/827 - (24%)

  Fly     5 NNVTA--ENCQFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIA 67
            |::.:  |....||.|||.:|:|||....|||..|.:.|::||||||::.:|:.|.|.|:.||:.
  Rat    44 NSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVR 108

  Fly    68 IMKLIDHPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 132
            |||.::||:::.|.:|.|.:|.|||::|:.|.||:|||||..||:..||||..||||:||:.:||
  Rat   109 IMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCH 173

  Fly   133 SHSICHRDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKAD 197
            ..:|.|||||.||||||.:.||||||||.::....||.|:|.||||.||.||:.:|:||||.:.|
  Rat   174 QKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVD 238

  Fly   198 VWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAE 262
            :||.|||||.|:.|:||||..||::|.|:|.||.:.:|.::..||:|:||..:.:||.:|.||.:
  Rat   239 IWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQ 303

  Fly   263 INRHPWVTAGGKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSH 327
            |.:..|:..|.:|| ||: |..|       |.....|...:..:..:|..:|:   |:|.|::..
  Rat   304 IMKDKWINIGYEGE-ELK-PYTE-------PEEDFGDTKRIEVMVGMGYTREE---IKEALTNQK 356

  Fly   328 NTEKVIYFLLLERK------RRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRINGTNAP---- 382
            ..|....:|||.||      |..|.|               |:...|...||  .|||::.
  Rat   357 YNEVTATYLLLGRKTEEGGDRGAPGL---------------ALARVRAPSDT--TNGTSSSKGSS 404

  Fly   383 -SYGQISEGSPLTPRRQAFNFRSYSSTRNHQRRSPTTV--------------------------- 419
             :.||.:..|....:|:..:|...|....|.:||||:.
  Rat   405 HNKGQRTSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGDTELKEERLPGRKASCSAAGSGSRGL 469

  Fly   420 -TSSVRSSSYHSPTRCNSPMSSAQQQANAISRPSS--PAAGTRHSTYGDRDRSG----------- 470
             .||...||.|:|.:...|    :::.::.|.|::  |:..||.:||...:|.|
  Rat   470 PPSSPMVSSAHNPNKAEIP----ERRKDSTSTPNNLPPSMMTRRNTYVCTERPGSERQSLLPNGK 530

  Fly   471 -HHSSVSRTP-----SH-----SSQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRGDCGIPP 524
             :.|..||.|     ||     |.::|           |:.|..::|....||..|||...|
  Rat   531 ENSSGTSRVPPASPSSHSLAPPSGERS-----------RLARGSTIRSTFHGGQVRDRRAGG--- 581

  Fly   525 GSPGGNSSGSTSASPSVHHRANSGPTIAISMFHDPDSNSVVNPNGSPMMNNSSPGMPGSPCNTPG 589
            ||.||..:| ..|||::.|.|  .|.                |:|.|               .|.
  Rat   582 GSGGGVQNG-PPASPTLAHEA--APL----------------PSGRP---------------RPT 612

  Fly   590 GQLWKTRLTNIKNSFLGSPRFHRR----KMQVSADEV---HL---TPESSPELTKRSWFGNLITT 644
            ..|: |:||:         :..||    ..::...||   ||   ..|::|.|.:..|...|.::
  Rat   613 TNLF-TKLTS---------KLTRRVTDEPERIGGPEVTSCHLPWDKAETAPRLLRFPWSVKLTSS 667

  Fly   645 EKDETFTILVKGKPIATVKAHLIHAFLSMAELSHSVVS-------PTSFRVEYKRNGNGPVMFQR 702
            ...|..                      ||.|..:..:       |..|.:.....|.|......
  Rat   668 RPPEAL----------------------MAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLS 710

  Fly   703 HVKFQVDISAICKQGDIADMLFALTFTLLSGNIRRFRRICEHIQSQV 749
            |  |:|::..:.:.|     |..:.|..::|....||.:...|.:.:
  Rat   711 H--FEVEVCQLPRPG-----LRGVLFRRVAGTALAFRTLVTRISNDL 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	130/252 (52%)
		UBA_BRSK	298..350	CDD:270525	15/57 (26%)
Mark4	NP_001178000.1	STKc_MARK	58..310	CDD:270974	129/251 (51%)
		UBA_MARK3_4	328..370	CDD:270590	10/44 (23%)
		MARK4_C	654..752	CDD:213382	21/126 (17%)