DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sff and Prkaa1

DIOPT Version :9

Sequence 1:	NP_648814.3	Gene:	sff / 39732	FlyBaseID:	FBgn0036544	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_062015.2	Gene:	Prkaa1 / 65248	RGDID:	3387	Length:	559	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	185/571 - (32%)
Similarity:	271/571 - (47%)	Gaps:	143/571 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKL-SESVLMKVEREIAIMKLIDHPHVL 78
            :|.|.|..|||.|..|.||:|.|.:.|.|||:||:||:|: |..|:.|:.|||..:||..|||::
  Rat    24 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHII 88

  Fly    79 GLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKP 143
            .|..|......:::::|:|||||||||:.|.|||..||:|:.|:||:|.:|:||.|.:.||||||
  Rat    89 KLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKP 153

  Fly   144 ENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYAL 208
            ||:|||...|.||||||::::...|..|.||||||:||.||||.|..|.|.:.|:||.|||||||
  Rat   154 ENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYAL 218

  Fly   209 LVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTAGG 273
            |.|.||||||::..|.:|:..|:|:.|.::.|...|||:.|::|:|.:|.|:.:|..|.|
  Rat   219 LCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEW----- 278

  Fly   274 KGELELELPMMEVVQTHVIP-----TATAVDPDVLNAIC-SLGCFKEKEKLIQELLSSSHNTE-- 330
               .:.:||      .::.|     ::|.:|.:.|..:| ...|.:|      |:||..:|..
  Rat   279 ---FKQDLP------KYLFPEDPSYSSTMIDDEALKEVCEKFECSEE------EVLSCLYNRNHQ 328

  Fly   331 ---KVIYFLLLERKRRRPALED------------DDE-------------IAQ--KSRSELDAVD 365
               .|.|.|:::.:|.....:|            ||.             :|:  ::|..||.::
  Rat   329 DPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELN 393

  Fly   366 PPRKR-----------------------LDTCR-----------INGTNAPSYGQISEGSPLT-- 394
            |.:.:                       .:.||           :|    |.|.::...:|:|
  Rat   394 PQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVN----PYYLRVRRKNPVTST 454

  Fly   395 ------------PRRQAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQANA 447
                        .|....:|||........:....|...|...|:|.|..|.:|
  Rat   455 FSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDS----------- 508

  Fly   448 ISRPSSPAAGTRHSTYGDRDRSGHHSSVSRTPSHSSQKSIEGDVVVVREPR 498
                             |.:..|..|.||.|.|.:|..|...||.    ||
  Rat   509 -----------------DAEAQGKPSEVSLTSSVTSLDSSPVDVA----PR 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	128/253 (51%)
		S_TKc	18..269	CDD:214567	127/251 (51%)
		UBA_BRSK	298..350	CDD:270525	14/69 (20%)
Prkaa1	NP_062015.2	STKc_AMPK_alpha	24..279	CDD:270981	129/262 (49%)
		UBA_AID_AAPK1	296..360	CDD:270586	15/69 (22%)
		AIS. /evidence=ECO:0000250	302..381		15/84 (18%)
		AMPKA1_C	404..557	CDD:213384	31/171 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..536		17/79 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100252
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810