Protein Alignment sff and Mark2

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: XP_006230941.1
• Gene: Mark2 / 60328
• RGDID: 708483
• Length: 841
• Species: Rattus norvegicus
• Alignment Length: 707
• Identity: 234/707 - (33%)
• Similarity: 350/707 - (49%)
• Gaps: 108/707 - (15%)

  Fly     1 MQKENNVT-AENCQFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVER 64
            ::..|:.| |:....:|.|||.||:|||....|||..|.:.||:||:|||::.:|:.|.|.|:.|
  Rat    35 LRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFR 99

  Fly    65 EIAIMKLIDHPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALD 129
            |:.|||:::||:::.|.:|.|.:|.|||::|:.||||:|||||..||:..||||..||||:||:.
  Rat   100 EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 164

  Fly   130 FCHSHSICHRDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGR 194
            :||...|.|||||.||||||...||||||||.::....|:.|:|.||||.||.||:.:|:||||.
  Rat   165 YCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229

  Fly   195 KADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLT 259
            :.||||.|||||.|:.|:||||..||::|.|:|.||.:.||.::..||::||:..:.:||.:|.|
  Rat   230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294

  Fly   260 LAEINRHPWVTAGGKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLS 324
            |.:|.:..|:..|.:.: ||: |.:|       |.....||.....:.|:|..:|:   ||:.|.
  Rat   295 LEQIMKDRWMNVGHEDD-ELK-PYVE-------PLPDYKDPRRTELMVSMGYTREE---IQDSLV 347

  Fly   325 SSHNTEKVIYFLLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRINGTNAPSYGQISE 389
            .....|.:..:|||..|...  || .|.|..|.|...|             :..::|||
  Rat   348 GQRYNEVMATYLLLGYKSSE--LE-GDTITLKPRPSAD-------------LTNSSAPS------ 390

  Fly   390 GSPLTPRRQAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNS-----PMSSAQQQANAIS 449
                 |..:.  .||.|:....:|.|...|.:...|:||...|:.|:     |.....::|::.:
  Rat   391 -----PSHKV--QRSVSANPKQRRSSDQAVPAIPTSNSYSKKTQSNNAENKRPEEETGRKASSTA 448

  Fly   450 R-PSSPAAG----------------------TRHSTYGDRDRSGHHS------SVSRTPSHSSQK 485
            : |:||..|                      :|:|...||...|..|      |::...|.:|..
  Rat   449 KVPASPLPGLDRKKTTPTPSTNSVLSTSTNRSRNSPLLDRASLGQASIQNGKDSLTMPGSRASTA 513

  Fly   486 SIEGDVVVVREPRIERRD---SLRQERGGGSPRDRGDC----------GIPPGSPGGNSSGSTSA 537
            |....|...| ||..::.   |:...:..|.|....:|          .:|..||..::..|:|.
  Rat   514 SASAAVSAAR-PRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSSG 577

  Fly   538 SPSVHHRANSGPTIAI-SMFHDPDSNSVVNPNGSPMMNNSSPGM-PGSPCNTPGGQLWKTRLTNI 600
            :|.   |.|....::. |.||......|.:....|.      |: |.||.....|:  :....:|
  Rat   578 APD---RTNFPRGVSSRSTFHAGQLRQVRDQQNLPF------GVTPASPSGHSQGR--RGASGSI 631

  Fly   601 KNSFLGSPRFHRRKMQVS-ADEVHLTPESSPEL--TKRSWFGNLITTEKDETFTILV 654
            .:.|  :.:|.||.:... |....|:...|.||  .::..|......|:.|..|:|:
  Rat   632 FSKF--TSKFVRRNLSFRFARRCRLSLPKSQELDILRQGSFCRQALVEQQEAHTLLL 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	132/252 (52%)
		UBA_BRSK	298..350	CDD:270525	15/51 (29%)
Mark2	XP_006230941.1	STKc_MARK	52..304	CDD:270974	131/251 (52%)
		UBA_MARK2	322..363	CDD:270589	12/43 (28%)
		MARK2_C	742..840	CDD:213386