Protein Alignment sff and mark4a

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: XP_021332218.1
• Gene: mark4a / 569346
• ZFINID: ZDB-GENE-060531-156
• Length: 762
• Species: Danio rerio
• Alignment Length: 673
• Identity: 222/673 - (32%)
• Similarity: 327/673 - (48%)
• Gaps: 129/673 - (19%)

  Fly     2 QKENNVTAEN----CQ-----------FVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINR 51
            :|..||::.:    |:           .:|.|||.||:|||....|||..|.:.||:||||||::
Zfish    27 EKGTNVSSRSLGARCRNSMASYSDELPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAIKIIDK 91

  Fly    52 EKLSESVLMKVEREIAIMKLIDHPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKE 116
            .:|:.:.|.|:.||:.|||.:.||:::.|.:|.|.:|.|||::|:.||||:|||||..||:...|
Zfish    92 TQLNPTSLQKLFREVRIMKTLHHPNIVQLFEVIETEKTLYLVMEYASGGEVFDYLVSHGRMKEIE 156

  Fly   117 ARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYA 181
            ||..||||:||:.:||..:|.|||||.||||||..:||||||||.::....|:.|:|.||||.||
Zfish   157 ARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDADSNIKIADFGFSNEFTLGNKLDTFCGSPPYA 221

  Fly   182 CPEVIRGEKYDGRKADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLL 246
            .||:.:|:||||.:.|:||.|||||.|:.|:||||..||::|.|:|.||.:.:|.::..||:.:|
Zfish   222 APELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRVPFYMSTDCEGIL 286

  Fly   247 RGMIEVNPDRRLTLAEINRHPWVTAGGKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGC 311
            |..:.:||.:|.||.::.:..|:.||..|:   ||      :.|:.||....|.:.:..:..:|.
Zfish   287 RRFLVLNPSKRCTLEQVMKDKWMNAGHDGD---EL------KPHIEPTEDYSDANRIEIMVGMGF 342

  Fly   312 FKEKEKLIQELLSSSHNTEKVIYFLLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRI 376
            ..|:.|  ..||:..:|.....|.||        .|:.:|....:....:..   ||.|.... .
Zfish   343 TTEEIK--DSLLNQKYNEVTATYLLL--------GLKTEDGAESRVSGSMTL---PRVRPSPI-T 393

  Fly   377 NGTNAPSYGQISEGSPLTPRRQAFNFRSYSSTRNHQ----------------RRSPTT------- 418
            ||||..|....|..|..:..:::.:  :|...|.|.                :||||:
Zfish   394 NGTNKHSSSSSSSSSSHSKTQRSAS--TYHRQRRHSDFFCSAGGPSMPVMHPKRSPTSGGDRELR 456

  Fly   419 -------------------VTSSVRSSSYHSPTRCNSPMSSAQQQANAISRPSSPAAGTRHSTYG 464
                               ..||...|:.::|.:...|....:..|...:.|.|..  ||.:||.
Zfish   457 ESRMPPRKASCSVMGSRTLPPSSPMVSTANNPNKAEIPDRRKEMTATTNNIPGSTM--TRRNTYV 519

  Fly   465 DRDRSG-----------HHSSVS-RTPSHS-----------SQKSIEGDVVVVREPRIERRDSLR 506
            ..|||.           .:||:| |.|..|           |..|..|:     ..|:.|..::|
Zfish   520 CTDRSSTDRHSLLQNGKDNSSLSHRLPPTSPSTLSIVGAGASSSSSSGE-----RCRLTRGSTIR 579

  Fly   507 QERGGGSPRDRGDCGIPPGSPGGNSSGSTSASPSVHHRANSGPTIAISMFHDPDSN--SVVNPNG 569
            ....||..|||    :||      :.|....||::.|.|.:.|..|.|.   ..||  |.:....
Zfish   580 STFHGGQLRDR----VPP------TYGPPPTSPTLSHDAGALPANARSR---ATSNLFSKLTSKL 631

  Fly   570 SPMMNNSSPGMPGSPCNTPGGQL 592
            :..::|.|.|:  |..:..||.|
Zfish   632 TRRVSNESEGV--SRSSVTGGHL 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	128/252 (51%)
		UBA_BRSK	298..350	CDD:270525	11/51 (22%)
mark4a	XP_021332218.1	STKc_MARK	57..309	CDD:270974	127/251 (51%)
		UBA_MARK3_4	327..369	CDD:270590	10/51 (20%)
		MARK4_C	662..762	CDD:213382