DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sff and brsk1b

DIOPT Version :9

Sequence 1:	NP_648814.3	Gene:	sff / 39732	FlyBaseID:	FBgn0036544	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_009297839.1	Gene:	brsk1b / 558390	ZFINID:	ZDB-GENE-131122-54	Length:	862	Species:	Danio rerio

Alignment Length:	900	Identity:	430/900 - (47%)
Similarity:	544/900 - (60%)	Gaps:	133/900 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AENCQFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLID 73
            ::..|:||||||||||||||||||||||||:..:||||||:|||||||||||||||||||:|||:
Zfish     9 SQAAQYVGPYRLEKTLGKGQTGLVKLGVHCITTQKVAIKIVNREKLSESVLMKVEREIAILKLIE 73

  Fly    74 HPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICH 138
            |||||.|.|||||.|||||:|||||||||||||||||||||||||||||||||||||||||||||
Zfish    74 HPHVLKLYDVYENNKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICH 138

  Fly   139 RDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGV 203
            ||||||||||||||||:||||||||||...|:||||||||||||||||||||||||:||||||||
Zfish   139 RDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRRADVWSCGV 203

  Fly   204 ILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPW 268
            ||:||||||||||.|||||||||||.||||:|||:|||||:|||||||||.::||||.||.:|||
Zfish   204 ILFALLVGALPFDHDNLRQLLEKVKSGVFHMPHFIPPDCQALLRGMIEVNAEKRLTLEEIQKHPW 268

  Fly   269 VTAGGKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVI 333
            . .||:.|...|.|....|....|.:.|.:|||||.::.|||||:::.||.::|.....|.||:|
Zfish   269 Y-QGGRNEPCPEQPPPRRVCVKRILSLTDLDPDVLESMHSLGCFRDRVKLTRDLQCEEENQEKLI 332

  Fly   334 YFLLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDT--------CRINGTNAPSYGQISEG 390
            |:|||:||.|.|:.||:.   ...|::   |||||||:|:        ||....:........:|
Zfish   333 YYLLLDRKERYPSYEDEH---LPPRND---VDPPRKRVDSPMLTRHGRCRPERKSLEVLSVTEQG 391

  Fly   391 SPLTPRRQAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQANAISRPSSPA 455
            ||..|||..       .|..|.:||        ||.|..|....:||:||.:......|:....:
Zfish   392 SPTPPRRAL-------DTSAHSQRS--------RSVSGASTGLSSSPLSSPRSPVFTFSQTEVTS 441

  Fly   456 AGTRHSTYGDRDRSGHHSSVSRTPSHSSQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRGDC 520
            |.   :|.....::|     |.|...:||::.|           ::..:|..:.....|..:...
Zfish   442 AS---ATQSKDPKAG-----SSTTPRASQRAPE-----------QKTQTLPTKAASDRPHLQSMK 487

  Fly   521 GIP---PGSPGGNSSGSTSASPSVHHRANSGPTIAISMFHD--PDSNSV--VNPNGSPM------ 572
            .:|   |.||..:.|...|..|.....|   |::..|:...  |:|..|  |.|.|||:
Zfish   488 SLPLQTPPSPSPSPSPLLSPIPRFFFPA---PSVLKSVTKTIYPNSAHVSQVTPQGSPLPTPLGT 549

  Fly   573 ----------------MNNSSPGMPG-------------SPCNTPGGQ---------LWKTRLTN 599
                            .::||....|             :|.::|||.         .|:|||.:
Zfish   550 PVHHPQHPPPTPPSSSSSSSSSRAEGGGGGGVGGGSLSLTPPSSPGGSGGMAASSSAHWRTRLNS 614

  Fly   600 IKNSFLGSPRFHRRKMQV--SADEVHLTPESSPELTKRSWFGNLITTEKDETFTILVKGKPIATV 662
            .||:.|||||||||::||  |.|...|||||||||.|:|||||.|:.|::|...::::.||::::
Zfish   615 FKNNLLGSPRFHRRRLQVPTSEDMSSLTPESSPELAKKSWFGNFISLEREEQIFVVIRDKPLSSI 679

  Fly   663 KAHLIHAFLSMAELSHSVVSPTSFRVEYKRNGNGPVMFQRHVKFQVDISAI------------CK 715
            ||.::|||||:..|||||:|.||||.|||.:| ||.:||:.|||||||:..            .:
Zfish   680 KADIVHAFLSIPSLSHSVISQTSFRAEYKSSG-GPSVFQKPVKFQVDIAFSEGERERERDKDRER 743

  Fly   716 QGDIADMLFALTFTLLSGNIRRFRRICEHIQSQVCSKRFP-----------GPSSPPTVTSVTQA 769
            :|.....::::|||||||..|||:|:.|.||:|:.|....           |.||.|..|. |:.
Zfish   744 EGRRETGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGLSSRPPSTP-TRQ 807

  Fly   770 VSESSSCGSVSSERLSYKRQVIENDMENDSIFSYKSGNGR---RASTTNNNNANP 821
            .|..|..|....||.....:...:.:........:.|:|:   |..::|...:.|
Zfish   808 NSRRSEGGGDRGERAERADRGEGSSIGGSVSVLQRKGSGKDKTRLLSSNGTQSQP 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	223/252 (88%)
		S_TKc	18..269	CDD:214567	221/250 (88%)
		UBA_BRSK	298..350	CDD:270525	26/51 (51%)
brsk1b	XP_009297839.1	STKc_BRSK1_2	16..269	CDD:270983	223/252 (88%)
		S_TKc	18..268	CDD:214567	220/249 (88%)
		UBA_BRSK	296..349	CDD:270525	26/52 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590370
Domainoid	1	1.000	465	1.000	Domainoid score	I449
eggNOG	1	0.900	-	-		E1_KOG0588
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302185at33208
OrthoFinder	1	1.000	-	-		FOG0002008
OrthoInspector	1	1.000	-	-		otm25070
orthoMCL	1	0.900	-	-		OOG6_100252
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1318
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.710