Protein Alignment sff and PRKAA2

DIOPT Version :9

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_006243.2
• Gene: PRKAA2 / 5563
• HGNCID: 9377
• Length: 552
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 183/582 - (31%)
• Similarity: 270/582 - (46%)
• Gaps: 121/582 - (20%)

  Fly    15 VGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKL-SESVLMKVEREIAIMKLIDHPHVL 78
            :|.|.|..|||.|..|.||:|.|.:.|.|||:||:||:|: |..|:.|::|||..:||..|||::
Human    13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHII 77

  Fly    79 GLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKP 143
            .|..|.......::::|:|||||||||:.|.||:...|||:.|:||:||:|:||.|.:.||||||
Human    78 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKP 142

  Fly   144 ENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYAL 208
            ||:|||...|.||||||::::...|..|.||||||:||.||||.|..|.|.:.|:||||||||||
Human   143 ENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYAL 207

  Fly   209 LVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTAGG 273
            |.|.|||||:::..|.:|::.|||:||.::.....:||..|::|:|.:|.|:.:|..|.|
Human   208 LCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEW----- 267

  Fly   274 KGELELELPMMEVVQTHVIP-----TATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEK-- 331
               .:.:||      :::.|     .|..:|.:.:..:|..  |:..|..:...|.|....::
Human   268 ---FKQDLP------SYLFPEDPSYDANVIDDEAVKEVCEK--FECTESEVMNSLYSGDPQDQLA 321

  Fly   332 VIYFLLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRINGTNAPSYGQISEGSPLTPR 396
            |.|.|:::.:|           .....||......|              ||...:.:.:...|
Human   322 VAYHLIIDNRR-----------IMNQASEFYLASSP--------------PSGSFMDDSAMHIP- 360

  Fly   397 RQAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQANAISRPSSPAAGTRHS 461
                     ...:.|..|.|              |...:||.:.....|...::|.|.|......
Human   361 ---------PGLKPHPERMP--------------PLIADSPKARCPLDALNTTKPKSLAVKKAKW 402

  Fly   462 TYGDRDRSGHHSSVSRTPSHSSQKSIEGDVVVVREPRIERR------------------------ 502
            ..|.|.:|..:..::.......|...|..||.....|:.|:
Human   403 HLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLL 467

  Fly   503 ------DSLRQERGGGS-------------PRDRGDCGIP-----PGSPGGNSSGSTSASPS 540
                  |.:.::|.|.|             ||...|....     .||..|:.:|||.:|.|
Human   468 DFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVS 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	128/253 (51%)
		S_TKc	18..269	CDD:214567	127/251 (51%)
		UBA_BRSK	298..350	CDD:270525	10/53 (19%)
PRKAA2	NP_006243.2	STKc_AMPK_alpha	13..268	CDD:270981	129/262 (49%)
		UBA_AID_AAPK2	285..349	CDD:270587	15/90 (17%)
		AIS. /evidence=ECO:0000250	291..376		19/135 (14%)
		AMPKA2_C	395..550	CDD:213385	25/135 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..521		9/43 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100252
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810