Protein Alignment sff and PRKAA1

DIOPT Version :9

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_996790.3
• Gene: PRKAA1 / 5562
• HGNCID: 9376
• Length: 574
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 177/541 - (32%)
• Similarity: 266/541 - (49%)
• Gaps: 127/541 - (23%)

  Fly    15 VGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKL-SESVLMKVEREIAIMKLIDHPHVL 78
            :|.|.|..|||.|..|.||:|.|.:.|.|||:||:||:|: |..|:.|:.|||..:||..|||::
Human    24 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHII 88

  Fly    79 GLSDVYENKKYLYLILEHVSGGELFDYLVKKGR---------------LTPKEARKFFRQIISAL 128
            .|..|......:::::|:|||||||||:.|.||               |..||:|:.|:||:|.:
Human    89 KLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGV 153

  Fly   129 DFCHSHSICHRDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDG 193
            |:||.|.:.||||||||:|||...|.||||||::::...|..|.||||||:||.||||.|..|.|
Human   154 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 218

  Fly   194 RKADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRL 258
            .:.|:||.||||||||.|.||||||::..|.:|:..|:|:.|.::.|...|||:.|::|:|.:|.
Human   219 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRA 283

  Fly   259 TLAEINRHPWVTAGGKGELELELPMMEVVQTHVIP-----TATAVDPDVLNAIC-SLGCFKEKEK 317
            |:.:|..|.|        .:.:||      .::.|     ::|.:|.:.|..:| ...|.:|
Human   284 TIKDIREHEW--------FKQDLP------KYLFPEDPSYSSTMIDDEALKEVCEKFECSEE--- 331

  Fly   318 LIQELLSSSHNTE-----KVIYFLLLERKRRRPALED------------DDE------------- 352
               |:||..:|..     .|.|.|:::.:|.....:|            ||.
Human   332 ---EVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFL 393

  Fly   353 IAQ--KSRSELDAVDPPRKR-----------------------LDTCR-----------INGTNA 381
            :|:  ::|..||.::|.:.:                       .:.||           :|
Human   394 VAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVN---- 454

  Fly   382 PSYGQISEGSPLT--------------PRRQAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPT 432
            |.|.::...:|:|              .|....:|||........:....|...|...|:|.|..
Human   455 PYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQ 519

  Fly   433 RCNSPMSSAQQQANAISRPSS 453
            |.:|. :.||.:::.:|..||
Human   520 RSDSD-AEAQGKSSEVSLTSS 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	128/268 (48%)
		S_TKc	18..269	CDD:214567	127/266 (48%)
		UBA_BRSK	298..350	CDD:270525	14/69 (20%)
PRKAA1	NP_996790.3	STKc_AMPK_alpha	24..294	CDD:270981	129/277 (47%)
		UBA_AID_AAPK1	311..375	CDD:270586	15/69 (22%)
		AMPKA1_C	419..572	CDD:213384	23/126 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100252
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810