Protein Alignment sff and sik1

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_001119855.1
• Gene: sik1 / 553465
• ZFINID: ZDB-GENE-030131-9446
• Length: 811
• Species: Danio rerio
• Alignment Length: 810
• Identity: 238/810 - (29%)
• Similarity: 350/810 - (43%)
• Gaps: 212/810 - (26%)

  Fly    15 VGPYRLEKTLGKGQTGLVKLGVHCV-----------IGKKVAIKIINREKLSESVLMKVEREIAI 68
            ||.|.:.:|||||...:|||..|.|           |..:||||||::.:|:.:.|.|:.||:.|
Zfish    23 VGFYEIIRTLGKGNFAVVKLARHKVTKTQAITTFYFIFMQVAIKIIDKTRLNSANLEKIYREVQI 87

  Fly    69 MKLIDHPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 133
            |||::|||::.|..|.|.|..||::.|:...||:||||...||::..||||.|.||::|:|:||.
Zfish    88 MKLLNHPHIIKLYQVMETKDMLYIVTEYAKNGEMFDYLTSNGRMSENEARKKFWQILTAVDYCHR 152

  Fly   134 HSICHRDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADV 198
            |.|.|||||.||||||...|||:||||..:...||..|.|.||||.||.|||..|::|:|.:.|:
Zfish   153 HHIVHRDLKTENLLLDANMNIKLADFGFGNFYNAGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDI 217

  Fly   199 WSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEI 263
            ||.||:||.|:.|:||||.|:|..|.::|..|.|.||.|:..||::|:|.|:.|:|.:|:|:|:|
Zfish   218 WSLGVVLYVLVCGSLPFDGDSLPALRQRVTEGRFRIPFFMSQDCENLIRKMLVVDPAKRITIAQI 282

  Fly   264 NRHPWVTAGGKG---ELELEL------------PMMEVVQTHVIPTATAVDPDVLNAICSLGCFK 313
            .:|.|:.|....   .|.|.|            |::.::||                   ||.
Zfish   283 KQHRWMLADPSAPHQTLSLSLTDYNSNLGDYSEPVLGIMQT-------------------LGI-- 326

  Fly   314 EKEKLIQELLSSSHNTEKVIYFLLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRING 378
            ::::.::.|.:||:|....||:|||||             .::.||:
Zfish   327 DRQRTVESLQNSSYNHFSAIYYLLLER-------------VKEHRSQ------------------ 360

  Fly   379 TNAPSYGQISEGSPLTPRRQ--AFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSA 441
                   |||        ||  |:|.||.:::.:.........:.|.|:|::...|:.|:|:.|.
Zfish   361 -------QIS--------RQCGAWNQRSRTASDSSTPEVIMESSDSFRNSAFPVATKVNAPIHSE 410

  Fly   442 Q--QQANAISRPSSPAAGTRHSTYGDRDRSGHHSSVSRTPSHSSQKSIEGDVVVVREPRIERRDS 504
            .  :|.....|...|...:.:....:|         |.:|:...:.:|..:   ||...:|..:.
Zfish   411 MECEQGGLFQRVVCPVEASLNGLLWNR---------SISPNSLLETTISEE---VRPHDLEEEEG 463

  Fly   505 LRQERGGGSPRDRGDCGIPPGSPGGNSSGSTSA--SPSVHHRANSGPTIAISMFHDPDSNSVV-- 565
            :.|.:             ||..|...|...|.|  |.|..|:. |.|.|.:|......|:|.:
Zfish   464 ILQVQ-------------PPHLPSTTSRRHTLAEVSTSRFHQC-SPPCIVVSPSDGASSDSCLKS 514

  Fly   566 ----NPNGSP--------MMNNSSPGMPGSPCNTPGGQLWKTRLTNIKNSFLGSPRFHRRKMQVS 618
                ||..||        :::.:.||..| |..||........|.|..:....|.:..||
Zfish   515 SSNTNPPLSPVVGDFSSLLISGTGPGALG-PAGTPLALSSNLLLQNQGSMLAASFQEGRR----- 573

  Fly   619 ADEVHLT---PESSPELTKRSWFGNLITTEKDETFTILVKGKPIATVKAHLIHAFLSMAELSHSV 680
            |.:..||   .....:|.|.:....|:...|       :||                   |:..|
Zfish   574 ASDTSLTQGLKAFRQQLRKNTRAKGLLGLNK-------IKG-------------------LARQV 612

  Fly   681 VSPTSFRVEYKRNGNGPVMFQRHVKFQVDISAICKQGDIADMLFALTFTLLSGNIRRFRRICEHI 745
            ..|:|.. ...|...||.|              |....:..          |...|..|.:.|.:
Zfish   613 CPPSSCS-RGSRGSLGPTM--------------CPPSSLQS----------SSGPRERRSMLEEV 652

  Fly   746 -------------QSQVCSKRFPGPSSPPT 762
                         |.||.......|||||:
Zfish   653 LHQQRMLQIQHQPQPQVQFLSQSHPSSPPS 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	127/263 (48%)
		UBA_BRSK	298..350	CDD:270525	13/51 (25%)
sik1	NP_001119855.1	STKc_SIK	25..288	CDD:270973	126/262 (48%)
		UBA_SIK1	309..358	CDD:270591	16/82 (20%)