Protein Alignment sff and Smok3a

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_001119517.1
• Gene: Smok3a / 545814
• MGIID: 3693943
• Length: 504
• Species: Mus musculus
• Alignment Length: 545
• Identity: 152/545 - (27%)
• Similarity: 245/545 - (44%)
• Gaps: 127/545 - (23%)

  Fly    18 YRLEKTLGKGQTGLVKLGVHCVIGKKVAIKII-NREKLSESVLMKVEREIAIMKLIDHPHVLGLS 81
            |.:.:|:|.|....|||..|.:.|..||:|.| .||.....|:.:||    ::.:.|||:::.|.
Mouse    28 YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIRKREYWCNRVISEVE----LLMMADHPNIISLL 88

  Fly    82 DVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENL 146
            .|.|.||.:|||:|...|..|:.::.|.|.|...|||..|:|::||:::||:..|.||||||:|:
Mouse    89 QVIETKKKVYLIMELCKGKSLYQHIRKAGYLQEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNI 153

  Fly   147 LLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVG 211
            ::::...:||.|||:.:....|..|...||:..::.|||:....|||.|.|||:.||:||.::.|
Mouse   154 MVEKDGKVKIIDFGLGTKVKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKIDVWTLGVVLYFMVTG 218

  Fly   212 ALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTAGGKGE 276
            .:|||..::::|::::..|.:.||..:..:.|.||..::..||..|.|:||:..|||||.|
Mouse   219 KIPFDACSIKKLVKRILAGKYSIPSRLSAELQDLLSLLMTANPKLRPTVAEVMVHPWVTEG---- 279

  Fly   277 LELELPMMEVVQTHVIP------TATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVIYF 335
                        :.|.|      |....||.::.|:..:| |:.::  |::.|......:.:..:
Mouse   280 ------------SGVFPDPCEEQTPLKPDPAIVKAMGHIG-FQAQD--IEDSLRQRKFNQTMASY 329

  Fly   336 LLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRINGTNAPSYGQISEGSPLTPRRQAF 400
            .||:::    .|::.|.             |.|.|                     |:.|....|
Mouse   330 CLLKKQ----ILKECDR-------------PTRAR---------------------PVNPSVTPF 356

  Fly   401 -NFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQANAISRPSSPAAGTRHSTYG 464
             :....::||...||..            :.|| |  |.|||.:|.:...:          ||..
Mouse   357 PSLVDTATTRLGLRRRE------------NEPT-C--PWSSANRQVSVCGK----------STSK 396

  Fly   465 DRDRSGHHSSVSRTPSHSSQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRG-------DCGI 522
            .|||.....||...|.|::             |.::...:          |.|.       .|.:
Mouse   397 KRDRRVSWPSVLGRPRHTA-------------PTMDHTRT----------RTRSVPCICSMFCTV 438

  Fly   523 PPGSPGGNSSGSTSASPS---VHHR 544
            .|.|...::.|.|.||.:   ||.|
Mouse   439 QPNSSEESTQGHTRASAADKPVHSR 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	94/251 (37%)
		UBA_BRSK	298..350	CDD:270525	10/51 (20%)
Smok3a	NP_001119517.1	STKc_AMPK-like	27..275	CDD:270905	93/250 (37%)
		UBA_MARK_Par1	295..334	CDD:270522	9/41 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..421		10/54 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..468		8/23 (35%)