DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sff and Brsk1

DIOPT Version :9

Sequence 1:	NP_648814.3	Gene:	sff / 39732	FlyBaseID:	FBgn0036544	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_001120809.1	Gene:	Brsk1 / 499073	RGDID:	1563268	Length:	778	Species:	Rattus norvegicus

Alignment Length:	870	Identity:	436/870 - (50%)
Similarity:	547/870 - (62%)	Gaps:	159/870 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ENCQFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDH 74
            ::.|:||||||||||||||||||||||||:.|:|||:||:|||||||||||||||||||:|||:|
  Rat    26 QHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAVKIVNREKLSESVLMKVEREIAILKLIEH 90

  Fly    75 PHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHR 139
            ||||.|.|||||||||||:|||||||||||||||||||||||||||||||:||||||||:|||||
  Rat    91 PHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHR 155

  Fly   140 DLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVI 204
            |||||||||||||||:||||||||||...|:||||||||||||||||:|||||||:||:||||||
  Rat   156 DLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVI 220

  Fly   205 LYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWV 269
            |:|||||||||||||||||||||||||||:|||:||||||||||||||.|::||:|.:|.:|||.
  Rat   221 LFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWY 285

  Fly   270 TAGGKGELELELPMMEV-----VQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNT 329
             .|||.|.:   |.:|.     |....:|:...:|||||.::.|||||:::|:|.:||.|...|.
  Rat   286 -LGGKHEPD---PCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQ 346

  Fly   330 EKVIYFLLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRI--NGTNAPSYGQI----- 387
            ||:||:|||:||.|.|:.||.|   ...|::   |||||||:|:..:  :|...|....:
  Rat   347 EKMIYYLLLDRKERYPSCEDQD---LPPRND---VDPPRKRVDSPMLSRHGKRRPERKSMEVLSI 405

  Fly   388 ----SEGSPLTPRRQAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQANAI 448
                |.|||: |.|:|.....:|    .:.||.:..::.:.||...||   .||:.|
  Rat   406 TDAGSGGSPV-PTRRALEMAQHS----QRSRSVSGASTGLSSSPLSSP---RSPVFS-------- 454

  Fly   449 SRPSSPAAGTRHSTYGDRDRSGHHSSVSRTPSHSSQKSIEGDVVVVREPRIERRDSLRQERGGG- 512
               .||..|.     ||..|.| .|..|:|.:..|                      |..||||
  Rat   455 ---FSPEPGV-----GDEARGG-GSPTSKTQTLPS----------------------RGPRGGGA 488

  Fly   513 -------SPRDRGDCGIPPGSPGGNSSGSTSASPSVHHRANSGPTIAISMFHDPDSNSVVNPNGS 570
                   |.|.....| |||||  .|||.|.                   .|.|......:|.|:
  Rat   489 GEQPPPPSARSTPLPG-PPGSP--RSSGGTP-------------------LHSPLHTPRASPTGT 531

  Fly   571 PMMNNSSPGMPGSPCNTPGGQLWKTRLTNIKNSFLGSPRFHRRKMQV-SADEV-HLTPESSPELT 633
            |   .::|  |.||....||..|::||.:|:|||||||||||||||| :|:|: .|||||||||.
  Rat   532 P---GTTP--PPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELA 591

  Fly   634 KRSWFGNLITTEKDETFTILVKGKPIATVKAHLIHAFLSMAELSHSVVSPTSFRVEYKRNGNGPV 698
            |||||||.|:.:|:|...:::|.||::::||.::|||||:..|||||:|.||||.|||.:| ||.
  Rat   592 KRSWFGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASG-GPS 655

  Fly   699 MFQRHVKFQVDISAI-------CKQGDIADMLFALTFTLLSGNIRRFRRICEHIQSQVCSKRFPG 756
            :||:.|:||||||:.       .:.|.....::::||||:||..|||:|:.|.||:|:.|..
  Rat   656 VFQKPVRFQVDISSSEGPEPSPRRDGSSGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTH--- 717

  Fly   757 PSSPPTVTSVTQAVSESSSCGSVSSERLSYKRQVIENDMENDSIFSYKSGNGRRASTTNNNNANP 821
              ..|:|    ||:::.                              |:|...|.:.|...:..|
  Rat   718 --DQPSV----QALADE------------------------------KNGAQTRPAGTPPRSLQP 746

  Fly   822 VDIPGSPIAVRSNSETAEHERNREL 846
            .  ||.|....|:|......::::|
  Rat   747 P--PGRPDPDLSSSPRRGPSKDKKL 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	221/252 (88%)
		S_TKc	18..269	CDD:214567	219/250 (88%)
		UBA_BRSK	298..350	CDD:270525	28/51 (55%)
Brsk1	NP_001120809.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		0/2 (0%)
		STKc_BRSK1_2	32..285	CDD:270983	221/252 (88%)
		S_TKc	34..284	CDD:214567	218/249 (88%)
		UBA_BRSK	314..367	CDD:270525	28/52 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..548		71/265 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	719..778		15/87 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	469	1.000	Domainoid score	I436
eggNOG	1	0.900	-	-		E1_KOG0588
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	727	1.000	Inparanoid score	I587
OMA	1	1.010	-	-		QHG45378
OrthoDB	1	1.010	-	-		D302185at33208
OrthoFinder	1	1.000	-	-		FOG0002008
OrthoInspector	1	1.000	-	-		otm44852
orthoMCL	1	0.900	-	-		OOG6_100252
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1318
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840