Protein Alignment sff and MARK3

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Alignment Length: 822
• Identity: 246/822 - (29%)
• Similarity: 374/822 - (45%)
• Gaps: 198/822 - (24%)

  Fly     9 AENCQFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLID 73
            |:....:|.|||.||:|||....|||..|.:.|::||||||::.:|:.:.|.|:.||:.|||:::
Human    47 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN 111

  Fly    74 HPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICH 138
            ||:::.|.:|.|.:|.||||:|:.||||:|||||..||:..||||..||||:||:.:||...|.|
Human   112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVH 176

  Fly   139 RDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGV 203
            ||||.||||||...||||||||.::....|..|:|.||||.||.||:.:|:||||.:.||||.||
Human   177 RDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGV 241

  Fly   204 ILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPW 268
            |||.|:.|:||||..||::|.|:|.||.:.||.::..||::||:..:.:||.:|.||.:|.:..|
Human   242 ILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRW 306

  Fly   269 VTAGGKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVI 333
            :.||.: |.||: |.:|       |.....|...::.:..:|..:|:   |||.||.....|...
Human   307 INAGHE-EDELK-PFVE-------PELDISDQKRIDIMVGMGYSQEE---IQESLSKMKYDEITA 359

  Fly   334 YFLLLERKRRRPALEDDDEIAQKSRSELDAVD-PPRKRLDTCRINGTNAPSYGQISEGSPLTPRR 397
            .:|||.||                .|||||.| .....|...::.    || ..::..:..:|..
Human   360 TYLLLGRK----------------SSELDASDSSSSSNLSLAKVR----PS-SDLNNSTGQSPHH 403

  Fly   398 QAFNFRSYSSTRNHQRRS-------PTTVTSSVRSSSYHSPTRCNSP-MSSAQQQANAIS----R 450
            :.  .||.||::..:|.|       |:.|....||.:..:.:..... :||.:...:|:.    .
Human   404 KV--QRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIA 466

  Fly   451 PSSPAAG-----------------------------TRHSTY--GDRDRSGHHSSV--------- 475
            |:||..|                             ||.:||  .:|..:..||.:
Human   467 PASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTI 531

  Fly   476 --SRTP---SHSSQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRGDCGI--PPGSPGGNSSG 533
              .|||   :||...:...|  .:|.|    |.:..:....|.||:|.....  ||
Human   532 PDQRTPVASTHSISSAATPD--RIRFP----RGTASRSTFHGQPRERRTATYNGPP--------- 581

  Fly   534 STSASPSVHHRANSGPTIAISMFHDPDSNSVVNPNGSPMMNNSSPGMPGSPCNTPGGQLWKTRLT 598
               ||||:.|.|                        :|:....|.|      :|.......::||
Human   582 ---ASPSLSHEA------------------------TPLSQTRSRG------STNLFSKLTSKLT 613

  Fly   599 NIKNSFLGSPRFHRR--------------KMQVSADEVHLTPESSPELTKRSWFGNLITTEKDET 649
            ....||    ||.:|              ...|||::.....|:.|...:.:|  ::.||...:.
Human   614 RRNMSF----RFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTW--SMKTTSSMDP 672

  Fly   650 FTILVKGKPIATVKAHLIHAFLSMAELSHSVVSPTSFRVEYKR-------NGNGPVMFQRHVKFQ 707
            ..:                    |.|: ..|:...:...|.:.       :|:|..  :..|:::
Human   673 GDM--------------------MREI-RKVLDANNCDYEQRERFLLFCVHGDGHA--ENLVQWE 714

  Fly   708 VDISAICKQGDIADMLFALTFTLLSGNIRRFRRICEHIQSQV 749
            ::   :||...::  |..:.|..:||....|:.|...|.:::
Human   715 ME---VCKLPRLS--LNGVRFKRISGTSIAFKNIASKIANEL 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	132/252 (52%)
		UBA_BRSK	298..350	CDD:270525	14/51 (27%)
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		STKc_MARK	55..307	CDD:270974	131/251 (52%)
		UBA_MARK3_4	325..367	CDD:270590	12/44 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600		56/278 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655		4/22 (18%)
		MARK1-3_C	654..751	CDD:213381	20/126 (16%)