DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sff and Nuak1

DIOPT Version :9

Sequence 1:	NP_648814.3	Gene:	sff / 39732	FlyBaseID:	FBgn0036544	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster

Alignment Length:	899	Identity:	216/899 - (24%)
Similarity:	356/899 - (39%)	Gaps:	252/899 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KTLGKGQTGLVKLGVHCVIGKKVAIKIINREKL-SESVLMKVEREIAIMKLIDHPHVLGLSDVYE 85
            |.||:|..|.|:||::...|::||||.|.:.|: :|:.|:::.||:.||..:.||:::.:.:|:|
  Fly    74 KKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFE 138

  Fly    86 NKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDE 150
            |::.:.|::|..:||||:|||.::..||.:|||:.|||:.:|:.:||.|.|||||||.||:||||
  Fly   139 NREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDE 203

  Fly   151 KNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPF 215
            |.|.||||||::::.....:|.|.||||.||.||::.|..|.|.:.|.||.||:||.|:.|::||
  Fly   204 KGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPF 268

  Fly   216 DDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTAGGKGELELE 280
            |..|.::|::::.:|.::.|. .|....:|:|.|:.|.|.:|.::.:|..|.||....      .
  Fly   269 DGSNFKRLVKQISQGDYYEPR-KPSRASTLIRDMLTVCPRKRASIEQICSHWWVNEND------N 326

  Fly   281 LPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVIYFLLLERKRRRP 345
            :..:::.:.  :...|.|..|||.::                                     .|
  Fly   327 VSCLDLAED--LANQTPVRLDVLLSL-------------------------------------TP 352

  Fly   346 ALEDDDEIAQKSRSELDAVDP------PRKRLDTCRINGTNAPSYGQISEGSPLTPRRQAFNFRS 404
            |....|::...|.....|...      ||..            |.|.|.:..|  |..:|
  Fly   353 ATITADQLVVPSAEGAAAAKAAANERVPRSH------------SVGSIRDMGP--PNTEA----- 398

  Fly   405 YSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQANAISRPSSPAAGTRHSTYGDRDRS 469
                   :||....|.:...::...||||..:|..|..|    ..|...|...|.::       :
  Fly   399 -------ERRILDMVAAGGEAALMPSPTRTITPAQSPVQ----TKRKLQPTVSTENA-------A 445

  Fly   470 GHHSSVSRTPSHSSQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRGDCGIPPGSPGGNSSGS 534
            |..:.....|::||       .|:.::                            |:|      .
  Fly   446 GTTAKKKEKPANSS-------FVISKD----------------------------GAP------L 469

  Fly   535 TSASPSV----------HHRANSGPTIAISMFHDPDSNSVVNPNG---SPMMNNSSPGMPGSPCN 586
            |.|.|::          ...||....:.:..:...|..:|    |   ..:|..::...|..|..
  Fly   470 TEAPPTIIEPQATLMEAETIANIPEEVPVPSYSQKDMQAV----GDICDLLMGTATTPAPAPPAP 530

  Fly   587 TP-GGQLWKTRL------------TNIKNSFLGSPRFHRRKMQVSADEVHLTPESS--------- 629
            || ..|..:.:|            |.:...|:..   |:     :||.|:...||:
  Fly   531 TPVARQPTRGKLDAVVETPEEKDATKVIKKFVNK---HK-----TADLVNAINESASKAAAPVSA 587

  Fly   630 ---PELTKRSWFGNLITTEKD----------ETFTILVKGKPIATVKAHLIHAFLSMAELSHSVV 681
               |...::....:..|..|.          ||........|:|.....      ...:||...|
  Fly   588 VAPPPFVRKCSLQDESTLNKFNAERRKSRILETAEKFQPPPPVAAAPPE------KPKKLSIPGV 646

  Fly   682 SPTSFRVEYKRNGNGPVMFQ----RHVKFQVDISAICKQGDIADMLFALTFTLLSGNIRRFRRIC 742
            |..||:.|:::....|...:    ..::.|..::|.......|:.|
  Fly   647 SVGSFKKEFEKKATNPPAAEGPTPGELRAQEQVAAAAAAAQEAETL------------------- 692

  Fly   743 EHIQSQVCSKRFPGPSSPPTVTSVTQAVSESSSCGSVSSERLSYKRQVIENDMENDSIFSYKSGN 807
                           |:||....|.|::..|.|..||:|..|...|:.:||.:
  Fly   693 ---------------STPPPSPVVAQSLEGSDSKNSVASISLDEARRSMENSI------------ 730

  Fly   808 GRRASTTNNNNANPVDIPGSPIAVRSNSETA-EHERNRELQSERQATTMSGSAI 860
             .......|.::..||...:.......||.| :.||.|:|::.|   .:.|:||
  Fly   731 -ALLLQAQNESSKEVDQLCAQTETIGVSEPATQQERERKLKNAR---AIIGNAI 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	106/247 (43%)
		S_TKc	18..269	CDD:214567	106/247 (43%)
		UBA_BRSK	298..350	CDD:270525	6/51 (12%)
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	106/247 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461609
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840