DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sff and snrkb

DIOPT Version :9

Sequence 1:	NP_648814.3	Gene:	sff / 39732	FlyBaseID:	FBgn0036544	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_957127.1	Gene:	snrkb / 393806	ZFINID:	ZDB-GENE-040426-1724	Length:	741	Species:	Danio rerio

Alignment Length:	682	Identity:	178/682 - (26%)
Similarity:	290/682 - (42%)	Gaps:	158/682 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHV 77
            :..|.|.|::|||||...:|||..|...|:.||:|:|::.||.:.....:.:|:..|||:.||:|
Zfish    11 KIAGLYDLDRTLGKGHFAVVKLARHVFTGQLVAVKVIDKTKLDDLATGHLLQEVRCMKLVQHPNV 75

  Fly    78 LGLSDVYENKKYLYLILEHVSGGELFDYLVK-KGRLTPKEARKFFRQIISALDFCHSHSICHRDL 141
            :.|.:|.:.:..||||||...||:::||::: :|.:....|:..|.||:.|:.:||...:.||||
Zfish    76 VRLYEVIDTQTKLYLILELGDGGDMYDYILRHEGGVAEDTAKVHFAQIVRAIAYCHRLHVVHRDL 140

  Fly   142 KPENLL-LDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVIL 205
            ||||:: ..::..:|:.|||.::....|:||.|||||..|:.||::.||:||....|:||.||||
Zfish   141 KPENVVFFRQQGTVKLTDFGFSNHFKPGTMLMTSCGSLAYSAPEILLGEEYDAPAVDIWSLGVIL 205

  Fly   206 YALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVT 270
            |.|:.|..||.:.|..:.|..:....:.:|:.:...|:.|:..|::.:|.:|.:||||..|||:
Zfish   206 YMLVCGHPPFQETNDSETLIMIMDCRYTVPNHISAQCKDLISRMLQRDPAKRASLAEIESHPWL- 269

  Fly   271 AGGKGELELELPMMEVVQTHVIPTATAVDPD----------------------VLNAICSLGCFK 313
                                     ..|||.                      :|.|:.| |...
Zfish   270 -------------------------QGVDPSPAGFTAAPLTSHRSLLPEEHEFILQAMTS-GSIA 308

  Fly   314 EKEKLIQELLSSSHNTEKVIYFLLLER----KRRRPALEDDDEIAQKSRSE-LDAVDPPRKRLDT 373
            .::.:.:.|.:..:|.....|:||.||    |:.:.:|..:....|:..|| ||.|... .|.||
Zfish   309 GRDAIQEALEADRYNHITATYYLLGERLLRDKQEQSSLTPEQRNTQRPISEPLDLVSQV-PRTDT 372

  Fly   374 CRIN--------GTNAPSY---GQISEGSPLTPR--RQAFNFRSYSSTRNHQRRSPTTVTSSVRS 425
            .|..        |:.:..|   |....|..|.|:  |...:|..:.||      :| .::.::|.
Zfish   373 LRGTPLSALAPLGSLSTGYVRRGVSESGDLLAPKANRHDNSFSDFCST------AP-CLSLNMRP 430

  Fly   426 SSYHSPT---------RCNS-------------------PMSSAQQQANAISRPSSPAAGT-RHS 461
            .....||         .|..                   |.:....:.:..|..|.|...| |||
Zfish   431 LPPDQPTVKSLGALQQICEEEEEEDEVKVKMAPGKLGPLPSTDLSLKPSRTSLQSEPQMRTGRHS 495

  Fly   462 TYG--------DRDRSGHHSSVS----RTP----SHSSQKSIEGDVVV--VREPRIERRDSLRQE 508
            :.|        :.:......|.|    :.|    |..|..::|..|.:  ..||::|..:..:|
Zfish   496 SKGMGNCETLAEEEEELEEGSESIEEHKKPLDLVSSISSGTVEHQVEMPPKTEPQVEEFNHTKQ- 559

  Fly   509 RGGGSPRDRGDCGIPPGSPGGNSSGSTSASPSVHHRAN--------SGPTIAISM--------FH 557
                           ||. |.:.|..|..|.|:..:..        .||..|..:        ..
Zfish   560 ---------------PGK-GNDKSVFTHVSLSLEEQEGEEIQGPNVDGPLPAPRLDVVQCCWGQR 608

  Fly   558 DPDSNSVVNPNGSPMMNN-SSPGMPGSPCNTP 588
            :|..:.:.|.|.:...:. ...|:..:||.:|
Zfish   609 EPSKDILENNNNTLAKSRLLEAGVISTPCGSP 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	99/254 (39%)
		S_TKc	18..269	CDD:214567	98/252 (39%)
		UBA_BRSK	298..350	CDD:270525	16/77 (21%)
snrkb	NP_957127.1	STKc_SNRK	12..269	CDD:270976	99/256 (39%)
		S_TKc	16..269	CDD:214567	98/252 (39%)
		UBA_SNRK	290..335	CDD:270524	9/45 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590374
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840