DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sff and CG8485

DIOPT Version :9

Sequence 1:	NP_648814.3	Gene:	sff / 39732	FlyBaseID:	FBgn0036544	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_610942.2	Gene:	CG8485 / 36579	FlyBaseID:	FBgn0033915	Length:	860	Species:	Drosophila melanogaster

Alignment Length:	889	Identity:	234/889 - (26%)
Similarity:	361/889 - (40%)	Gaps:	206/889 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHV 77
            :..|.|.||:|||.|...:|||..|...|.|||:|::::.||.:.....:.:|:..|||:.||:|
  Fly    15 KIAGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQEVRCMKLVQHPNV 79

  Fly    78 LGLSDVYENKKYLYLILEHVSGGELFDYLVK-KGRLTPKEARKFFRQIISALDFCHSHSICHRDL 141
            :.|.:|.:.:..|||:||...||:|:||::| ...|:.:.|||:||||:.|:.:||...:.||||
  Fly    80 VRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCHQLHVVHRDL 144

  Fly   142 KPENLLLDEK-NNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVIL 205
            ||||::..|| ..:|:.|||.::....|..|||.|||..|:.||::.|:.||....|:||.||||
  Fly   145 KPENVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPAVDIWSLGVIL 209

  Fly   206 YALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVT 270
            |.|:.|..||:..|..:.|..:....:.:|..|..||:.|:..|:..:|.:|.|:.||....|:.
  Fly   210 YMLVCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEIASSAWLK 274

  Fly   271 AGGKGELELELPMMEVVQT-----HVIPTATA----------VDPDVLNAICSLGCFKEKEKLIQ 320
                       |:.|...|     |.:|..:.          :...::|     |....||:::|
  Fly   275 -----------PIDEPDSTTSTSEHFLPLVSREQLGEEDHAFIIQKMIN-----GNIASKEEILQ 323

  Fly   321 ELLSSSHNTEKVIYFLLLE-RKRRRPALEDDDEIAQKSRSELDAV----DPPRKRLDTCRINGTN 380
            .|..:.:|.....||||.| |.|||     .:|:|||.|...||.    |..||.:       ..
  Fly   324 ALDKNKYNHITATYFLLAELRLRRR-----REELAQKQRLLNDASMKVGDASRKLV-------PE 376

  Fly   381 APSYGQISEGS-PL----TPRRQAFNFRSYSSTRNHQRRSPTTVTSSVR-SSSYHSPTRCNS--- 436
            .||..:..:|. |:    ||..|..|.......|:.:       .|.|| .....|.|.|.:
  Fly   377 KPSPTEAQKGGVPISINVTPAAQFANDGGKPDKRSRK-------CSIVREEDEEESATECTAVGN 434

  Fly   437 ---PMSSAQQQANAISRPSSPAAGTRHSTYGDRDRSGHHSSVSRTPSHSSQKSIEG-DVVVVRE- 496
               ..||::::|.:.| |.|.:...|.|:.......|...:.|..||||..|.:.. |..:..:
  Fly   435 ELKVTSSSRREAFSDS-PFSRSIHERSSSEPGNQTKGEQIANSGVPSHSRTKIVVSVDATLAHKL 498

  Fly   497 PRIERRDSLRQER-GGGSPRDRGDCGIPPGSPGGNSSGSTSASPSVHHRANS-----GPTIAISM 555
            .::|:...:.::. .|....:.|.....|         |:|.:|.:.||...     .|:.:.|.
  Fly   499 KQMEKSAKIDEDTLSGLKELEIGKLKPLP---------SSSKNPVLTHRRTKLNKIRTPSCSSSE 554

  Fly   556 FHDPDSNSVVNPNGSPMMNNSSPGMPGSPCNTPGGQLWKTRLTNIKNSFLGSP----RFHRR--- 613
            ..|.|:                                |||.....|.|:|..    |.|||
  Fly   555 ASDDDT--------------------------------KTRNKKKINKFVGDTPVRFRMHRRDSH 587

  Fly   614 -KMQVSADEVHLTPESSPELTKRSWFGNLITTEKDETFTILVKGKPIATVKAHLIHAFLSMAELS 677
             ....|.|:::..|.|:      |..||.|:....      |.||                 :..
  Fly   588 DDSSDSQDQLYPPPGSA------SNAGNFISKSGS------VSGK-----------------KEG 623

  Fly   678 HSVVSPTSFRVEYKRNGNGPVMFQRHVKFQVDISAICKQGDIADMLFALTFTLLSGN-IRRFRRI 741
            .|.....:.:.:..|..:.....::|.|..||      :...|:...|.:.|..:|| ..|.|||
  Fly   624 QSQYKEPNNKSDENRKSHSQKNRKQHNKDHVD------KHSHAERQLADSSTATTGNSTNRRRRI 682

  Fly   742 CEHIQSQVCSKRFPGPSSPPTVTSVTQ--------AVSESSSCGSVSSERLSYKRQVIENDMEND 798
            .|   ||          |...:|...:        |.||::|..|.|::.:..:..::..:....
  Fly   683 RE---SQ----------SLDRITEAQEYEMRHRCYAESEAASSSSSSTQHIDQRYSLLSLNTSTF 734

  Fly   799 SIFSYKSGNGRRASTTN----------------------NNNAN 820
            |:...|......|..||                      |||.|
  Fly   735 SVAETKEEYDEEADATNATDQIMNTLNAAKATLQQEQYFNNNTN 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	102/254 (40%)
		S_TKc	18..269	CDD:214567	101/252 (40%)
		UBA_BRSK	298..350	CDD:270525	16/52 (31%)
CG8485	NP_610942.2	STKc_SNRK	16..273	CDD:270976	102/256 (40%)
		S_TKc	20..273	CDD:214567	101/252 (40%)
		UBA_SNRK	296..338	CDD:270524	7/46 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461627
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940