Protein Alignment sff and mark3a

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: XP_021336197.1
• Gene: mark3a / 334300
• ZFINID: ZDB-GENE-030131-6232
• Length: 746
• Species: Danio rerio
• Alignment Length: 794
• Identity: 239/794 - (30%)
• Similarity: 353/794 - (44%)
• Gaps: 162/794 - (20%)

  Fly    15 VGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHVLG 79
            :|.|||.||:|||....|||..|.:.|.:||||:|::.:|:.:.|.|:.||:.|||.::||:::.
Zfish    54 IGNYRLLKTIGKGNFAKVKLARHILTGSEVAIKMIDKTQLNPTSLQKLSREVTIMKNLNHPNIVK 118

  Fly    80 LSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPE 144
            |.:|.|.:|.|:|::|:.||||:|||||..||:..||||..||||:||:.:||...|.|||||.|
Zfish   119 LFEVIETEKTLFLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAE 183

  Fly   145 NLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALL 209
            |||||...||||||||.::....||.|:|.||||.||.||:.:|:||||.:.||||.|||||.|:
Zfish   184 NLLLDGDMNIKIADFGFSNEFMVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLV 248

  Fly   210 VGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTAGGK 274
            .|:||||..||::|.|:|.||.:.||.::..||::||:..:.:||.:|.||.:|.:..|:.:|.:
Zfish   249 SGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKERWINSGFE 313

  Fly   275 GELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVIYFLLLE 339
            .: ||: |..|       |.|...|...::.|..:|..|||   |.|.|...:..|....:|||.
Zfish   314 DD-ELK-PFTE-------PDADISDQKRIDVIVGMGFSKEK---IHESLFKMNYDEVTAIYLLLG 366

  Fly   340 RKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRINGTNAPSYGQISEGSPLTPRRQAFNFRS 404
            ||..       :|::..|.:...:|...|...:.    .:.:||:.::.              ||
Zfish   367 RKTH-------EEVSDSSSNSNLSVAKTRPSSEM----NSQSPSHLKVQ--------------RS 406

  Fly   405 YSS-----TRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQANAISR------PSSPAAGT 458
            .||     :|.|..:......:::.:|....|...:   |..:|:...|:|      |.||..|.
Zfish   407 ISSSESRKSRRHSEQVGVVANNALSNSKRVVPVTAD---SEVKQEGGVIARKLPNHSPPSPLLGN 468

  Fly   459 RHSTYGDR--DRSGHHSSVSRTPSHSSQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRGDCG 521
            .::.....  ||...:|..|...|.|...|.....|.......:|...:
Zfish   469 ANNPNKTEIPDRKKGNSITSNNISGSGSMSRRNTYVCTERNNTDRLSVI---------------- 517

  Fly   522 IPPGSPGGNSSGSTSASPSVHHRANSGPTIAISMFHDPDSNSVVNPNGSPMMN------------ 574
                 |.|..: |.|.|||  .|.....|.:||....||....  |.||...:
Zfish   518 -----PNGKEN-SVSLSPS--SRDPGASTHSISTSVTPDKTRF--PRGSASRSTFHGQVRDRRTA 572

  Fly   575 --NSSPGMPGSPCNTPGGQLWKTRLTN--------------IKNSFLGSPRFHRRKMQVSADEVH 623
              |..|..|..|.:........|:||:              :...|..|.||......||.|:
Zfish   573 TYNGPPASPAQPRSRANANNLLTKLTSKLTRRNMSFRFSKRVSTEFERSGRFEGSSRHVSGDQ-- 635

  Fly   624 LTPESSPELTKRSWFGNLITTEKDETFTILVKGKPIATVKAHLIHAFLSMAELSHSVVSPTSFRV 688
                                 :|||       ||.....|...:....||.  :.|.:.|.....
Zfish   636 ---------------------QKDE-------GKDGKDGKPRSLRFTWSMN--TTSTMEPADIIN 670

  Fly   689 EYKR--NGNGPVMFQRH----------------VKFQVDISAICKQGDIADMLFALTFTLLSGNI 735
            |.:.  :.|.....||.                |:::::   :||...::  |..:.|..:|||.
Zfish   671 EIRTVLDANSCSYQQRECFLLLCAHGDSHTDSLVQWEME---VCKLPRLS--LNGVRFKRISGNS 730

  Fly   736 RRFRRICEHIQSQV 749
            ..|:.|...|..::
Zfish   731 IAFKNIASKIAGEL 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	130/252 (52%)
		UBA_BRSK	298..350	CDD:270525	15/51 (29%)
mark3a	XP_021336197.1	STKc_MARK	56..308	CDD:270974	129/251 (51%)
		UBA_like_SF	326..368	CDD:473871	13/44 (30%)
		MARK1-3_C	647..744	CDD:213381	20/103 (19%)