Protein Alignment sff and melk

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_996771.2
• Gene: melk / 30724
• ZFINID: ZDB-GENE-990603-5
• Length: 676
• Species: Danio rerio
• Alignment Length: 631
• Identity: 199/631 - (31%)
• Similarity: 289/631 - (45%)
• Gaps: 127/631 - (20%)

  Fly    18 YRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHVLGLSD 82
            |.:.:|:|.|....||||.|.:.|:||||||:.::.|.:. |.:|:.||..||.:.|.||..|..
Zfish    13 YEVYETIGSGGFAKVKLGRHKLTGEKVAIKIMEKKDLGDD-LPRVKIEIEAMKNLSHQHVCRLYH 76

  Fly    83 VYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLL 147
            |.|....:|::||:..|||||||::.|.||:.:|.|.|||||||||.:.||....||||||||||
Zfish    77 VIETTSKIYMVLEYCPGGELFDYIIAKDRLSEEETRVFFRQIISALAYVHSQGYAHRDLKPENLL 141

  Fly   148 LDEKNNIKIADFGMASLQPAGSM---LETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALL 209
            :||.:|:|:.|||:.: :|.|.:   |.|.||||.||.||:|:|:.|.|.:|||||.||:|||||
Zfish   142 IDEDHNLKLIDFGLCA-KPKGGLGFELLTCCGSPAYAAPELIQGKAYIGSEADVWSMGVLLYALL 205

  Fly   210 VGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTAGGK 274
            .|.|||||||...|..|:.||.:..||::.|....||..|::|:|.||||:..:..|||...|
Zfish   206 CGFLPFDDDNCMVLYRKITRGKYSNPHWLSPSSILLLNQMMQVDPKRRLTVKHLLDHPWAMRG-- 268

  Fly   275 GELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKE-KEKLIQELLSSSHNTEKVIYFLLL 338
                ...|    |:.|.......:|.|.:..:..  .||: |::.||.:....::.....|.|||
Zfish   269 ----YSTP----VEWHSKYPLGHIDEDCITEMAV--TFKQSKQRTIQLVSEWKYDQITATYLLLL 323

  Fly   339 ERKRR-RPA---------------------------LEDDDEIAQKSRSELDAVDPPRKRLDTCR 375
            .:||: ||.                           .||||.:.......:  |.||     .|
Zfish   324 AKKRQGRPVRLRAECPVIDIVCSPLQDMQLKKSLRFTEDDDGVHPVVLGSM--VFPP-----DC- 380

  Fly   376 INGTNAPSYGQISEGSPLTPRR----------------QAFNFRSYSSTRNHQRRSPTTVTSSVR 424
                    |...:..:||||:.                :.:|..:||....|.|  |.......|
Zfish   381 --------YDDENPWTPLTPKNTHTTNTPRMKLYPETTEKWNEMAYSPVIEHSR--PCRQKPERR 435

  Fly   425 SSSYHSPTRCNSPMSSAQQQANAISRPSSPAAGTRHSTYGDRDRSGHHSSVSRTPSHSSQKSIE- 488
            ..:  ...:.|..:........|:..|.:|.:..:..:         :.:|..||:|::.||.|
Zfish   436 DRT--KENKENLAVPGTDGDVFALPAPRTPTSSRKVKS---------NRTVMTTPNHNNNKSSEV 489

  Fly   489 --GDVVVVREPRIERRDSLRQERGGG---------SPR------DRGDCGIPPGS--PGGNSSGS 534
              |.....:|.  .||..:.|::.|.         ||.      |...|.:..|.  .||...||
Zfish   490 NKGAGSATKEG--SRRREVEQQQNGQQGELNMLAFSPERRSRSLDLAGCQVDSGQKRKGGKVFGS 552

  Fly   535 ---------TSASPSVHHRANSGP-----TIAISMFHDPDSNSVVN 566
                     |..:||.......||     ...:::.:..:::.|:|
Zfish   553 LERGLDKVITMLTPSKKRGPRDGPRKIKAQYNVTLTNQTNADQVLN 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	126/253 (50%)
		UBA_BRSK	298..350	CDD:270525	16/80 (20%)
melk	NP_996771.2	STKc_MELK	9..264	CDD:270980	125/252 (50%)
		UBA_MELK	283..334	CDD:270526	15/52 (29%)
		UBA-like. /evidence=ECO:0000250	284..323		9/40 (23%)
		Autoinhibitory region. /evidence=ECO:0000250	328..673		55/302 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..518		21/109 (19%)
		MELK_C	577..671	CDD:213383	2/22 (9%)