Protein Alignment sff and SIK2

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_056006.1
• Gene: SIK2 / 23235
• HGNCID: 21680
• Length: 926
• Species: Homo sapiens
• Alignment Length: 843
• Identity: 237/843 - (28%)
• Similarity: 352/843 - (41%)
• Gaps: 223/843 - (26%)

  Fly    15 VGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHVLG 79
            ||.|.:|.|||||...:||||.|.:...:||||||::.:|....|.|:.||:.|||::||||::.
Human    17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIK 81

  Fly    80 LSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPE 144
            |..|.|.|..|||:.|:...||:||||...|||...|||:.|.||:||:|:||...|.|||||.|
Human    82 LYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAE 146

  Fly   145 NLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALL 209
            |||||...||||||||..:...:|.:|.|.||||.||.|||..|::|:|.:.|:||.||:||.|:
Human   147 NLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLV 211

  Fly   210 VGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTAGGK 274
            .||||||...|..|.::|..|.|.||:|:..||:.|:|.|:.::|.:|||:|:|..|.|:..
Human   212 CGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLI--- 273

  Fly   275 GELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVIYFLLLE 339
             |:.::.|::...:....|:....:..||..:.|||.  :::|.|:.|.:.|:|....|||||:|
Human   274 -EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGI--DQQKTIESLQNKSYNHFAAIYFLLVE 335

  Fly   340 RKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRINGTNAPSYGQISEGSPLTPRRQAFNFRS 404
            |             .:..||..    |..:|||
Human   336 R-------------LKSHRSSF----PVEQRLD-------------------------------- 351

  Fly   405 YSSTRNHQRRSPTTVTSSV-RSSSYHSPTRCNSP-----MSSAQQQANAISRPSSPAAGTRHSTY 463
                 ..|||..|....:| ::.:...|...:||     .|:...||:.:...|.||:|
Human   352 -----GRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASG------ 405

  Fly   464 GDRDRSGHHSSVSRTPSHSSQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRGDCGIPPGSP- 527
                                   .:.:...:.|..::            :|:..| |.:.|..|
Human   406 -----------------------CQAEAAFMEEECVD------------TPKVNG-CLLDPVPPV 434

  Fly   528 ----GGNSSGSTSASPSVHH------RANSGPTIAISMFHDPDSNS------------VVNPNGS 570
                |..|..|.....|:..      .|...|..|...|....|..            ||.|...
Human   435 LVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAG 499

  Fly   571 PMMN-NSSPGMPGSPCNTPGGQLWKTRLTNIKNSFLGSPRFHRRKMQVSADEVHLTPESSPELTK 634
            .:.: |.||.:.........|.:.:.     .|....:|         |..::.|..:.||.:|
Human   500 KIFSMNDSPSLDSVDSEYDMGSVQRD-----LNFLEDNP---------SLKDIMLANQPSPRMT- 549

  Fly   635 RSWFGNLITTEKDETFTILVKGKPIATVKAHLIHAFLSMAELSHSVVSPTSFRVEYKRNGN---- 695
                         ..|..|....|       .:.|..|.....|: .||.||| |.:|..:
Human   550 -------------SPFISLRPTNP-------AMQALSSQKREVHN-RSPVSFR-EGRRASDTSLT 592

  Fly   696 -GPVMFQRHVKFQVDISAICKQGDIADMLFALTFTLLSGNIRRFRRICEHIQSQVCSKRFPGPSS 759
             |.|.|::|::                            |:.|.:.|.|..:.|:..::. ||.:
Human   593 QGIVAFRQHLQ----------------------------NLARTKGILELNKVQLLYEQI-GPEA 628

  Fly   760 PPTVTSVTQAVSE-SSSC---------GSVS----------SERLSYKRQVIENDMENDSIFS 802
            .|.:......:.: :|||         .|||          |.|.|.:.|.:::.::..|:.|
Human   629 DPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLS 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	128/252 (51%)
		UBA_BRSK	298..350	CDD:270525	17/51 (33%)
SIK2	NP_056006.1	STKc_SIK	19..271	CDD:270973	127/251 (51%)
		UBA_SIK2	297..341	CDD:270592	17/58 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	644..666		6/21 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	742..776
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	801..896