Protein Alignment sff and MARK2

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_001034558.2
• Gene: MARK2 / 2011
• HGNCID: 3332
• Length: 788
• Species: Homo sapiens
• Alignment Length: 827
• Identity: 252/827 - (30%)
• Similarity: 384/827 - (46%)
• Gaps: 158/827 - (19%)

  Fly     3 KENNVTAENCQFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIA 67
            :.:..:|:....:|.|||.||:|||....|||..|.:.||:||:|||::.:|:.|.|.|:.||:.
Human    38 RNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVR 102

  Fly    68 IMKLIDHPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 132
            |||:::||:::.|.:|.|.:|.|||::|:.||||:|||||..||:..||||..||||:||:.:||
Human   103 IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 167

  Fly   133 SHSICHRDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKAD 197
            ...|.|||||.||||||...||||||||.::....|:.|:|.||||.||.||:.:|:||||.:.|
Human   168 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVD 232

  Fly   198 VWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAE 262
            |||.|||||.|:.|:||||..||::|.|:|.||.:.||.::..||::||:..:.:||.:|.||.:
Human   233 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297

  Fly   263 INRHPWVTAGGKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSH 327
            |.:..|:..|.:.: ||: |.:|       |.....||.....:.|:|..:|:   ||:.|....
Human   298 IMKDRWMNVGHEDD-ELK-PYVE-------PLPDYKDPRRTELMVSMGYTREE---IQDSLVGQR 350

  Fly   328 NTEKVIYFLLLERKRRRPALEDDDEIAQKSRSELD-----AVDP-----------PRKRLDTCRI 376
            ..|.:..:|||..|...  || .|.|..|.|...|     |..|           |::|..:.:.
Human   351 YNEVMATYLLLGYKSSE--LE-GDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQA 412

  Fly   377 NGTNAP---SYG---QISEGSPLTPRRQAFNFRSYSSTR----------NHQRRSPTTVTSSVRS 425
            .|...|   ||.   |.:......|.....:.|..|||.          ..::.:||..|:||.|
Human   413 AGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLS 477

  Fly   426 SSYHSPTRCNSPM--------SSAQQQANAISRPSSPAAGTRHSTYGDRDRSGHHSSVSRTPSHS 482
            :|.:...  |||:        :|.|...::::.|     |:|.||      :...::||......
Human   478 TSTNRSR--NSPLLERASLGQASIQNGKDSLTMP-----GSRAST------ASASAAVSAARPRQ 529

  Fly   483 SQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRGDCGIPPGSPGGNSSGSTSASPSVHHRANS 547
            .|||:..              |:...:..|.|....:|.:|  .|.........||||.|:.::|
Human   530 HQKSMSA--------------SVHPNKASGLPPTESNCEVP--RPSTAPQRVPVASPSAHNISSS 578

  Fly   548 G----------PTIAISMFHDPDSNSVVNPNGSPMMNNSSPGM-PGSPCNTPGGQLWKTRLTNIK 601
            |          ...:.|.||......|.:....|.      |: |.||.....|:  :....:|.
Human   579 GGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPY------GVTPASPSGHSQGR--RGASGSIF 635

  Fly   602 NSFLG-------SPRFHRRKMQ--VSADEVH-LTP----------------ESSPELTKRSWFGN 640
            :.|..       |.||.||.:.  .|.|.|. |.|                |:.|...:.:|  :
Human   636 SKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTW--S 698

  Fly   641 LITT---EKDETFTILVKGKPIATVKAHLIHAFLSMAELSHSVVSPTSFRVEYKRNGNGPVMFQR 702
            :.||   |.:|....:.|.....:.::.|...::.:.  .|.......|
Human   699 MKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLC--MHGTPGHEDF---------------- 745

  Fly   703 HVKFQVDISAICKQGDIADMLFALTFTLLSGNIRRFRRICEHIQSQV 749
             |:::::   :||...::  |..:.|..:||....|:.|...|.:::
Human   746 -VQWEME---VCKLPRLS--LNGVRFKRISGTSMAFKNIASKIANEL 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	132/252 (52%)
		UBA_BRSK	298..350	CDD:270525	15/51 (29%)
MARK2	NP_001034558.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		1/7 (14%)
		STKc_MARK	52..304	CDD:270974	131/251 (52%)
		UBA_MARK2	322..363	CDD:270589	12/43 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	373..632		63/295 (21%)
		MARK2_C	689..787	CDD:213386	20/124 (16%)