Protein Alignment sff and pig-1

DIOPT Version :10

• Sequence 1: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_001294353.1
• Gene: pig-1 / 176877
• WormBaseID: WBGene00021012
• Length: 706
• Species: Caenorhabditis elegans
• Alignment Length: 733
• Identity: 209/733 - (28%)
• Similarity: 324/733 - (44%)
• Gaps: 151/733 - (20%)

  Fly    16 GPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHVLGL 80
            |.|.:...||.|..|.|:|..|.:..:|||||||::::|... |.:|:.|:..::.:.|.::..|
 Worm     9 GFYAVHDELGSGGFGKVRLATHLLTNQKVAIKIIDKKQLGHD-LPRVQTEMDALRNLSHQNICRL 72

  Fly    81 SDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPEN 145
            ....|.:...::::|:.||||:|||:|:|.||...|||.||||::||:.|.||....||||||||
 Worm    73 YHYIETEDKFFIVMEYCSGGEMFDYIVRKERLEESEARHFFRQLVSAIAFVHSQGYAHRDLKPEN 137

  Fly   146 LLLDEKNNIKIADFGMASLQPAGSM----LETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILY 206
            |||.|..::|:.|||:.:....|.:    |:|.||||.||.||:|:|.:|.|.:|||||.|::||
 Worm   138 LLLTEDLHLKLIDFGLCAKTEKGRIDKHNLDTCCGSPAYAAPELIQGLQYKGNEADVWSMGILLY 202

  Fly   207 ALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTA 271
            .||||||||:|||::.:.:|::.|.|:.|.|:.|..:.|||.|::|.|:||:::.::..|.|
 Worm   203 TLLVGALPFEDDNMQIMYKKIQSGCFYEPEFLSPLSKQLLRAMLQVVPERRISVKKLLEHDW--- 264

  Fly   272 GGKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVIYFL 336
                   |.....:.|:.:.|.....:|.||...:.....|:..:|:|:::...:.:.....|:.
 Worm   265 -------LNHKYTQPVKWNTIYDKNFIDRDVARVMSKYYGFESTDKMIEKIKEWNFDYMTSTYYA 322

  Fly   337 LLERKRR--------------------------------------RPALEDDDEIAQKSRSELDA 363
            ||.|||.                                      :..|||||.......|..|.
 Worm   323 LLHRKRNGMEIILPMVRNSTNTAPPNVQNILCSPTIHASLENNLDKSGLEDDDSDPSSISSSSDI 387

  Fly   364 VDPPRKRLDTCRINGTNAPSYGQISEGSPLTPRRQAFNFRSYSSTRNHQRRSPTTVTSSVRSSSY 428
            ....:|   .|.::..::.|    ....|::|..:.....||.   |.....|:..|.
 Worm   388 SARLKK---NCVVSDESSSS----RFVKPMSPAAEKDKKMSYV---NAMLTMPSQFTG------- 435

  Fly   429 HSPTRC-NSPMSSAQQQANAISRPSSPAAG------TRHSTYGDRDRSGHHSSVSRTP------S 480
            .||.|. .||||.....:.::...::|:.|      ..:::.|...|.|..:..||.|      .
 Worm   436 RSPLRIPESPMSVRSSDSASLGSAATPSRGGVKDNDKENASTGKNYRMGASTCKSRGPLKITGVE 500

  Fly   481 HSSQKSIEGDVVVVREPRIERRDSLR----------QERGGGSPRDRGDCGIPPGSPGGNSSGST 535
            ..:.||      |...|  ..|.:||          ::|......||...|:|||||  .|.||.
 Worm   501 EGTMKS------VYTTP--NTRPTLRGLFSPGNAEHKKRQRARSSDRASIGMPPGSP--VSIGSA 555

  Fly   536 SASPSVHHRANSGPTIAISMFHDPDSNSVVNPNGSPMMNNSSPGMPGSPCNTPGGQLWKTRLTNI 600
                   |.||               |.::....:|.....:..:|         |...|.|...
 Worm   556 -------HSAN---------------NELLADGRTPRSRIKTNRLP---------QRVFTSLERK 589

  Fly   601 KNSF--LGSPR-FHRRKMQVSAD-----EVHLTPESSPELTKRSWFGNLI-TTEKDETFTILVKG 656
            |...  |.:|| ..|...||..|     .|.:|....||..:     ||: ....||.....:.|
 Worm   590 KEKLITLLTPRKMQRDSPQVLKDVKNMVNVSMTASQDPEEVR-----NLLKKVFDDERMRYELNG 649

  Fly   657 -KPIATVKAHLIHAFLSM 673
             |.:||.:.  :|.::::
 Worm   650 WKFLATQET--VHGWMTV 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	112/256 (44%)
		UBA_BRSK	298..350	CDD:270525	14/89 (16%)
pig-1	NP_001294353.1	STKc_MELK	7..265	CDD:270980	113/266 (42%)
		UBA_MELK	284..335	CDD:270526	12/50 (24%)
		MELK_C	611..703	CDD:213383	14/62 (23%)